RT Journal Article SR Electronic T1 Epidemiological comparison of the first and second waves of the COVID-19 pandemic in Nigeria, February 2020–April 2021 JF BMJ Global Health JO BMJ Global Health FD BMJ Publishing Group Ltd SP e007076 DO 10.1136/bmjgh-2021-007076 VO 6 IS 11 A1 Akande, Oluwatosin Wuraola A1 Elimian, Kelly Osezele A1 Igumbor, Ehimario A1 Dunkwu, Lauryn A1 Kaduru, Chijioke A1 Olopha, Olubunmi Omowunmi A1 Ohanu, Dabri Olohije A1 Nwozor, Lilian A1 Agogo, Emmanuel A1 Aruna, Olusola A1 Balogun, Muhammad Shakir A1 Aderinola, Olaolu A1 Ahumibe, Anthony A1 Arinze, Chinedu A1 Badaru, Sikiru Olanrewaju A1 Nwachukwu, William A1 Dada, Augustine Olajide A1 Erameh, Cyril A1 Hamza, Khadeejah A1 Mohammed, Tarik Benjamin A1 Ndodo, Nnaemeka A1 Obiekea, Celestina A1 Ofoegbunam, Chinenye A1 Ogunbode, Oladipo A1 Ohonsi, Cornelius A1 Tobin, Ekaete Alice A1 Yashe, Rimamdeyati A1 Adekaiyaoja, Afolabi A1 Asuzu, Michael C. A1 Audu, Rosemary Ajuma A1 Bello, Muhammad Bashir A1 Bello, Shaibu Oricha A1 Deeni, Yusuf Yahaya A1 Disu, Yahya A1 Joseph, Gbenga A1 Ezeokafor, Chidiebere A1 Habib, Zaiyad Garba A1 Ibeh, Christian A1 Ike, Ifeanyi Franklin A1 Iwara, Emem A1 Luka-Lawal, Rejoice Kudirat A1 Namara, Geoffrey A1 Okwor, Tochi A1 Olajide, Lois A1 Ilesanmi, Oluwafunke Olufemi A1 Omonigho, Solomon A1 Oyiri, Ferdinand A1 Takpa, Koubagnine A1 Ugbogulu, Nkem Usha A1 Ibekwe, Priscilla A1 Oladejo, John A1 Ilori, Elsie A1 Ochu, Chinwe Lucia A1 Ihekweazu, Chikwe YR 2021 UL http://gh.bmj.com/content/6/11/e007076.abstract AB Background With reports of surges in COVID-19 case numbers across over 50 countries, country-level epidemiological analysis is required to inform context-appropriate response strategies for containment and mitigation of the outbreak. We aimed to compare the epidemiological features of the first and second waves of COVID-19 in Nigeria.Methods We conducted a retrospective analysis of the Surveillance Outbreak Response Management and Analysis System data of the first and second epidemiological waves, which were between 27 February and 24 October 2020, and 25 October 2020 to 3 April 2021, respectively. Descriptive statistical measures including frequencies and percentages, test positivity rate (TPR), cumulative incidence (CI) and case fatality rates (CFRs) were compared. A p value of <0.05 was considered statistically significant. All statistical analyses were carried out in STATA V.13.Results There were 802 143 tests recorded during the study period (362 550 and 439 593 in the first and second waves, respectively). Of these, 66 121 (18.2%) and 91 644 (20.8%) tested positive in the first and second waves, respectively. There was a 21.3% increase in the number of tests conducted in the second wave with TPR increasing by 14.3%. CI during the first and second waves were 30.3/100 000 and 42.0/100 000 respectively. During the second wave, confirmed COVID-19 cases increased among females and people 30 years old or younger and decreased among urban residents and individuals with travel history within 14 days of sample collection (p value <0.001). Most confirmed cases were asymptomatic at diagnosis during both waves: 74.9% in the first wave; 79.7% in the second wave. CFR decreased during the second wave (0.7%) compared with the first wave (1.8%).Conclusion Nigeria experienced a larger but less severe second wave of COVID-19. Continued implementation of public health and social measures is needed to mitigate the resurgence of another wave.Data are available on reasonable request. Data may be made available on request, subject to compliance with the Nigeria Centre for Disease Control (NCDC) data sharing policy.