RT Journal Article SR Electronic T1 Conducting clinical research in a resource-constrained setting: lessons from a longitudinal cohort study in The Gambia JF BMJ Global Health JO BMJ Global Health FD BMJ Publishing Group Ltd SP e006419 DO 10.1136/bmjgh-2021-006419 VO 6 IS 8 A1 Abdulazeez Imam A1 Oghenebrume Wariri A1 Tida Dibbasey A1 Abdoulie Camara A1 Anthony Mendy A1 Assan N Sanyang A1 Masaneh Ceesay A1 Samba Jallow A1 Abdoulie E Jallow A1 Kaddijatou Bah A1 Njilan Johnson A1 Ebrima Trawally A1 Dawda Sowe A1 Alansana Darboe A1 Beate Kampmann A1 Olubukola T Idoko YR 2021 UL http://gh.bmj.com/content/6/8/e006419.abstract AB Clinical research conducted to Good Clinical Practice (GCP) standards is increasingly being undertaken in resource-constrained low-income and middle-income countries (LMICs) settings. This presents unique challenges that differ from those faced in high-income country (HIC) contexts, due to a dearth of infrastructure and unique socio-cultural contexts. Field experiences by research teams working in these LMIC contexts are thus critical to advancing knowledge on successful research conduct in these settings. The Medical Research Council Unit The Gambia at London School of Hygiene and Tropical Medicine has operated in The Gambia, a resource-constrained LMIC for over 70 years and has developed numerous research support platforms and systems. The unit was the lead clinical collaborator in a recently completed Expanded Program on Immunization Consortium (EPIC) study, involving a multicountry collaboration across five countries including the USA, Canada, Belgium, Papua New Guinea and The Gambia. The EPIC study recruited and completed follow-up of 720 newborn infants over 2 years. In this paper, we provide in-depth field experience covering challenges faced by the Gambian EPIC team in the conduct of this study. We also detail some reflections on these challenges. Our findings are relevant to the international research community as they highlight practical day-to-day challenges in conducting GCP standard clinical research in resource-constrained LMIC contexts. They also provide insights on how study processes can be adapted early during research planning to mitigate challenges.There are no data in this work.