PT - JOURNAL ARTICLE AU - Briggs, Andrew M AU - Huckel Schneider, Carmen AU - Slater, Helen AU - Jordan, Joanne E AU - Parambath, Sarika AU - Young, James J AU - Sharma, Saurab AU - Kopansky-Giles, Deborah AU - Mishrra, Swatee AU - Akesson, Kristina E AU - Ali, Nuzhat AU - Belton, Joletta AU - Betteridge, Neil AU - Blyth, Fiona M AU - Brown, Richard AU - Debere, Demelash AU - Dreinhöfer, Karsten E AU - Finucane, Laura AU - Foster, Helen E AU - Gimigliano, Francesca AU - Haldeman, Scott AU - Haq, Syed A AU - Horgan, Ben AU - Jain, Anil AU - Joshipura, Manjul AU - Kalla, Asgar A AU - Lothe, Jakob AU - Matsuda, Shuichi AU - Mobasheri, Ali AU - Mwaniki, Lillian AU - Nordin, Margareta C AU - Pattison, Marilyn AU - Reis, Felipe J J AU - Soriano, Enrique R AU - Tick, Heather AU - Waddell, James AU - Wiek, Dieter AU - Woolf, Anthony D AU - March, Lyn TI - Health systems strengthening to arrest the global disability burden: empirical development of prioritised components for a global strategy for improving musculoskeletal health AID - 10.1136/bmjgh-2021-006045 DP - 2021 Jun 01 TA - BMJ Global Health PG - e006045 VI - 6 IP - 6 4099 - http://gh.bmj.com/content/6/6/e006045.short 4100 - http://gh.bmj.com/content/6/6/e006045.full SO - BMJ Global Health2021 Jun 01; 6 AB - Introduction Despite the profound burden of disease, a strategic global response to optimise musculoskeletal (MSK) health and guide national-level health systems strengthening priorities remains absent. Auspiced by the Global Alliance for Musculoskeletal Health (G-MUSC), we aimed to empirically derive requisite priorities and components of a strategic response to guide global and national-level action on MSK health.Methods Design: mixed-methods, three-phase design.Phase 1: qualitative study with international key informants (KIs), including patient representatives and people with lived experience. KIs characterised the contemporary landscape for MSK health and priorities for a global strategic response.Phase 2: scoping review of national health policies to identify contemporary MSK policy trends and foci.Phase 3: informed by phases 1–2, was a global eDelphi where multisectoral panellists rated and iterated a framework of priorities and detailed components/actions.Results Phase 1: 31 KIs representing 25 organisations were sampled from 20 countries (40% low and middle income (LMIC)). Inductively derived themes were used to construct a logic model to underpin latter phases, consisting of five guiding principles, eight strategic priority areas and seven accelerators for action.Phase 2: of the 165 documents identified, 41 (24.8%) from 22 countries (88% high-income countries) and 2 regions met the inclusion criteria. Eight overarching policy themes, supported by 47 subthemes, were derived, aligning closely with the logic model.Phase 3: 674 panellists from 72 countries (46% LMICs) participated in round 1 and 439 (65%) in round 2 of the eDelphi. Fifty-nine components were retained with 10 (17%) identified as essential for health systems. 97.6% and 94.8% agreed or strongly agreed the framework was valuable and credible, respectively, for health systems strengthening.Conclusion An empirically derived framework, co-designed and strongly supported by multisectoral stakeholders, can now be used as a blueprint for global and country-level responses to improve MSK health and prioritise system strengthening initiatives.All data relevant to the study are included in the article or uploaded as supplemental information.