RT Journal Article SR Electronic T1 Patterns and trends in causes of child and adolescent mortality 2000–2016: setting the scene for child health redesign JF BMJ Global Health JO BMJ Global Health FD BMJ Publishing Group Ltd SP e004760 DO 10.1136/bmjgh-2020-004760 VO 6 IS 3 A1 Kathleen L Strong A1 Jon Pedersen A1 Emily White Johansson A1 Bochen Cao A1 Theresa Diaz A1 Regina Guthold A1 Danzhen You A1 Jennifer Requejo A1 Li Liu YR 2021 UL http://gh.bmj.com/content/6/3/e004760.abstract AB The under-5 mortality rate has declined from 93 deaths per 1000 live births in 1990 to 39 per 1000 live births in 2018. This improvement in child survival warrants an examination of age-specific trends and causes of death over time and across regions and an extension of the survival focus to older children and adolescents. We examine patterns and trends in mortality for neonates, postneonatal infants, young children, older children, young adolescents and older adolescents from 2000 to 2016. Levels and trends in causes of death for children and adolescents under 20 years of age are based on United Nations Inter-agency Group for Child Mortality Estimation for all-cause mortality, the Maternal and Child Epidemiology Estimation group for cause of death among children under-5 and WHO Global Health Estimates for 5–19 year-olds. From 2000 to 2016, the proportion of deaths in young children aged 1–4 years declined in most regions while neonatal deaths became over 25% of all deaths under 20 years in all regions and over 50% of all under-5 deaths in all regions except for sub-Saharan Africa which remains the region with the highest under-5 mortality in the world. Although these estimates have great variability at the country level, the overall regional patterns show that mortality in children under the age of 5 is increasingly concentrated in the neonatal period and in some regions, in older adolescents. The leading causes of disease for children under-5 remain preterm birth and infectious diseases, pneumonia, diarrhoea and malaria. For older children and adolescents, injuries become important causes of death as do interpersonal violence and self-harm. Causes of death vary by region.