RT Journal Article SR Electronic T1 The COVID-19 pandemic: diverse contexts; different epidemics—how and why? JF BMJ Global Health JO BMJ Global Health FD BMJ Publishing Group Ltd SP e003098 DO 10.1136/bmjgh-2020-003098 VO 5 IS 7 A1 Wim Van Damme A1 Ritwik Dahake A1 Alexandre Delamou A1 Brecht Ingelbeen A1 Edwin Wouters A1 Guido Vanham A1 Remco van de Pas A1 Jean-Paul Dossou A1 Por Ir A1 Seye Abimbola A1 Stefaan Van der Borght A1 Devadasan Narayanan A1 Gerald Bloom A1 Ian Van Engelgem A1 Mohamed Ali Ag Ahmed A1 Joël Arthur Kiendrébéogo A1 Kristien Verdonck A1 Vincent De Brouwere A1 Kéfilath Bello A1 Helmut Kloos A1 Peter Aaby A1 Andreas Kalk A1 Sameh Al-Awlaqi A1 NS Prashanth A1 Jean-Jacques Muyembe-Tamfum A1 Placide Mbala A1 Steve Ahuka-Mundeke A1 Yibeltal Assefa YR 2020 UL http://gh.bmj.com/content/5/7/e003098.abstract AB It is very exceptional that a new disease becomes a true pandemic. Since its emergence in Wuhan, China, in late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, has spread to nearly all countries of the world in only a few months. However, in different countries, the COVID-19 epidemic takes variable shapes and forms in how it affects communities. Until now, the insights gained on COVID-19 have been largely dominated by the COVID-19 epidemics and the lockdowns in China, Europe and the USA. But this variety of global trajectories is little described, analysed or understood. In only a few months, an enormous amount of scientific evidence on SARS-CoV-2 and COVID-19 has been uncovered (knowns). But important knowledge gaps remain (unknowns). Learning from the variety of ways the COVID-19 epidemic is unfolding across the globe can potentially contribute to solving the COVID-19 puzzle. This paper tries to make sense of this variability—by exploring the important role that context plays in these different COVID-19 epidemics; by comparing COVID-19 epidemics with other respiratory diseases, including other coronaviruses that circulate continuously; and by highlighting the critical unknowns and uncertainties that remain. These unknowns and uncertainties require a deeper understanding of the variable trajectories of COVID-19. Unravelling them will be important for discerning potential future scenarios, such as the first wave in virgin territories still untouched by COVID-19 and for future waves elsewhere.