PT - JOURNAL ARTICLE AU - Eili Y Klein AU - Katie K Tseng AU - Suraj Pant AU - Ramanan Laxminarayan TI - Tracking global trends in the effectiveness of antibiotic therapy using the Drug Resistance Index AID - 10.1136/bmjgh-2018-001315 DP - 2019 Apr 01 TA - BMJ Global Health PG - e001315 VI - 4 IP - 2 4099 - http://gh.bmj.com/content/4/2/e001315.short 4100 - http://gh.bmj.com/content/4/2/e001315.full SO - BMJ Global Health2019 Apr 01; 4 AB - Background Evaluating trends in antibiotic resistance and communicating the results to a broad audience are important for dealing with this global threat. The Drug Resistance Index (DRI), which combines use and resistance into a single measure, was developed as an easy-to-understand measure of the effectiveness of antibiotic therapy. We demonstrate its utility in communicating differences in the effectiveness of antibiotic therapy across countries.Methods We calculated the DRI for countries with data on antibiotic use and resistance for the disease-causing organisms considered by the WHO as priority pathogens: Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus faecium and Enterococcus faecalis. Additionally, we estimated pooled worldwide resistance rates for these pathogens.Results 41 countries had the requisite data and were included in the study. Resistance and use rates were highly variable across countries, but A. baumannii resistance rates were uniformly higher, on average, than other organisms. High-income countries, particularly Sweden, Canada, Norway, Finland and Denmark, had the lowest DRIs; the countries with the highest DRIs, and therefore the lowest effectiveness of antibiotic therapy, were all low-income and middle-income countries.Conclusions The DRI is a useful indicator of the problem of resistance. By combining data on antibiotic use with resistance, it captures a snapshot of how the antibiotics a country typically uses match their resistance profiles. This single measure of the effectiveness of antibiotic therapy provides a means of benchmarking against other countries and can, over time, indicate changes in drug effectiveness that can be easily communicated.