TY - JOUR T1 - Formulating questions to explore complex interventions within qualitative evidence synthesis JF - BMJ Global Health JO - BMJ Global Health DO - 10.1136/bmjgh-2018-001107 VL - 4 IS - Suppl 1 SP - e001107 AU - Andrew Booth AU - Jane Noyes AU - Kate Flemming AU - Graham Moore AU - Özge Tunçalp AU - Elham Shakibazadeh Y1 - 2019/01/01 UR - http://gh.bmj.com/content/4/Suppl_1/e001107.abstract N2 - When making decisions about complex interventions, guideline development groups need to factor in the sociocultural acceptability of an intervention, as well as contextual factors that impact on the feasibility of that intervention. Qualitative evidence synthesis offers one method of exploring these issues. This paper considers the extent to which current methods of question formulation are meeting this challenge. It builds on a rapid review of 38 different frameworks for formulating questions. To be useful, a question framework should recognise context (as setting, environment or context); acknowledge the criticality of different stakeholder perspectives (differentiated from the target population); accommodate elements of time/timing and place; be sensitive to qualitative data (eg, eliciting themes or findings). None of the identified frameworks satisfied all four of these criteria. An innovative question framework, PerSPEcTiF, is proposed and retrospectively applied to a published WHO guideline for a complex intervention. Further testing and evaluation of the PerSPEcTiF framework is required. ER -