Background COVID-19 remains a public health threat globally. As part of control measures, the Zambian government integrated it into the IDSR, hence the need to regularly analyse COVID-19 data to inform decisions. This analysis was done to assess COVID-19 descriptively, and to generate hypothesis of factors associated with its mortalities in Monze district.

Methods Between 31st October 2022 and 9th December 2022, we conducted a cross-sectional review of COVID-19 cases and mortalities for the period 1st June 2020 to 30th June 2022. Data were extracted from COVID-19 line list and analysed using EpiInfo. Results were presented in tables and graphs.

Results Between June 2020 and June 2022, Monze district recorded 3141 cases of COVID-19, where 54.2% (1702/3141) were females however, 66% (51/77) of males died of COVID-19 compared to females. The median age was 31 years (IQR 22 – 43) with case fatality rate of 2.5% (77/3141). Most 71.3% (2239/3141) of those who were infected reside in urban area. Majority 28.4% (891/3141) of cases were from 21 – 30 years whilst most 53.2% (41/77) of mortalities were from 71 years and above. Most 29% (912/3141) of cases and 32.5% (25/77) mortalities occurred in June 2021. Sex and age were associated with COVID-19 mortalities.

Conclusion More females were infected whilst more males died from COVID-19. The most infected age group was 21 – 30 years. Higher mortalities were recorded in the age group 71 years and above. Majority of the cases were from urban areas. Most cases and mortalities occurred in June 2021. Further studies are required to determine higher reported cases among females, urban settings, 21–30 age group and deaths in the elderly.