Background The National Health Research Authority (NHRA) is implementing a program under the name institutionalization of research and knowledge translation (KT) in Zambia as a means to enhance evidence-based decision-making and ultimately improve health outcomes. The institutionalization of research and KT involves the integration of systematic research processes and the effective translation of research findings into policies and practices within the national health system. NHRA recognizes the critical role that research plays in informing health policies, programs, and interventions.

Methods In order to actualize this program, the NHRA utilized a multi-faceted methodology. This involved carrying out a needs assessment of the ten (10) provinces in Zambia to identify the research and knowledge translation gaps for key personnel. Consequently, the NHRA conducted a research priority setting for each of the ten (10) provinces, through stakeholder engagements, to identify and prioritize research topics/areas aligned with Zambia’s health needs and policy priorities. NHRA also developed a robust frameworks to assess the impact of research and knowledge translation activities in the provinces.

Results The NHRA has since created Terms of References (TORs) and facilitated the appointment of Research and Knowledge Translation Focal Point Persons (R&KT FPPs) in all the ten (10) provinces to spearhead research and knowledge translation activities within respective provinces. Consequently, with support from CDC foundation, NHRA has engaged the R&KT FPPs in its research and knowledge translation training and KT mentorship programs. The R&KT FPPs have been trained in Research Methods and Scientific Writing, as well as a KT mentorship course dubbed as Data to Policy.

Conclusion With greater funding and partnership, it is hoped that the program will cascade to the lower levels (district, facility and community) within the Ministry of Health for better health outcomes. Undoubtedly, this initiative represents a crucial and timely step towards evidence-based decision-making and improved health outcomes.