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  • PA-785 Characterization of anti-SARS-CoV-2 humoral immunity among health care workers in hospitals from the islands of Santiago and São Vicente, Cabo Verde

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PA-785 Characterization of anti-SARS-CoV-2 humoral immunity among health care workers in hospitals from the islands of Santiago and São Vicente, Cabo Verde
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  1. Inês Rodrigues1,
  2. Kleidi Santos2,
  3. Tamar Monteiro2,
  4. Mérita Fidalgo3,
  5. Jacqueline Monteiro2,
  6. Ofélia Monteiro4,
  7. Janaína Vicente5,
  8. José Luis Spencer3,
  9. Isaquel Silva6,
  10. Elsi Ca6,
  11. Lidia Nhamussua7,
  12. Sebastian Nielsen6,8,
  13. Pedro Aide7,
  14. Paulo Ferrinho9,
  15. Frederik Schaltz-Buchholzer6,8,10,
  16. Maria da Luz Lima Mendonça11,
  17. António Pedro Delgado2,
  18. Christine Stabell Benn6,8,10,
  19. Inês Fronteira9,12,
  20. Isabel De Pina Araújo2
  1. 1Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Portugal
  2. 2Faculdade de Ciências e Tecnologia, Universidade de Cabo Verde, Cabo Verde
  3. 3Hospital Central Dr. Baptista de Sousa, Ministério da Saúde de Cabo Verde, Cabo Verde
  4. 4Hospital Central Dr. Agostinho Neto, Ministério da Saúde de Cabo Verde, Cabo Verde
  5. 5Hospital Regional Santa Rita Vieira, Ministério da Saúde de Cabo Verde, Cabo Verde
  6. 6Bandim Health Project, Guiné-Bissau
  7. 7Centro de Investigação em Saúde de Manhiça, Moçambique
  8. 8Danish institute for Advanced Study, University of Southern Denmark, Denmark
  9. 9Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Portugal
  10. 10Bandim Health Project, OPEN, Department of Clinical Research, University of Southern Denmark, Denmark
  11. 11Instituto Nacional de Saúde Pública de Cabo verde, Ministério da Saúde, Cabo Verde
  12. 12National School of Public Health, Public Health Research Centre, Comprehensive Health Research Center, NOVA University of Lisbon, Portugal

Abstract

Background Health Care Workers (HCW) faced a high risk of exposure to SARS-CoV-2.

In the present study, we described the presence and duration of anti-S and anti-N IgG antibodies against SARS-CoV-2 among HCW to evaluate the immunity response induced by either SARS-CoV-2 infection or COVID-19 vaccination.

Methods Case-cohort study of 465 HCW from hospitals from the islands of Santiago and São Vicente, conducted in 2021, of which 217 were cases (SARS-CoV-2 infection) and 248 controls (no SARS-CoV-2 infection). Study participants were followed-up until 6 months after recruitment for longitudinal analysis of antibody dynamics, independently of SARS-CoV-2 vaccination status. ELISA test for anti-N and anti-S1 SARS-CoV-2 IgG antibodies were performed on serum samples using collected at baseline (T0) and at 6 months (T6). Among vaccinated participants, these two time points corresponded to a mean time from vaccination of 115 (SD: 60 days) and 350 days (SD: 74 days) respectively.

Results Of the 396/465 (85%) tested for anti-SARS-CoV-2 antibodies at T0, 36% (n=66/185) of cases and 12% of controls (n=26/211) were positive for anti-N.

Among the vaccinated at T0 165/166 (96%) cases and 200/205 (97%) controls were positive for anti-S1.

The anti-S1 among the case and control group remained high at T6, with 177/179 (99%) cases and 197/198 (99%) controls of HCW tested at 6 months being positive.

Among 250 (67%) vaccinated, who were anti-N negative at T0-,115(32%) remain negative at T6.

Conclusion These findings showed that only 31% of cases had anti-N. The results also showed positive results for IgG anti-N in HCW without previous SARS-CoV-2 infection, which could be considered asymptomatic cases. Most vaccinated participants had Anti-S after vaccination and they remained high during the 6 months of follow-up. Nonetheless, at least (65/354) had a new infection (32 cases, 33 controls).

Funding: EDCTP (RIA2020EF-3049)

https://doi.org/10.1136/bmjgh-2023-EDC.299

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