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Abstracts of Oral Presentations
OA-322 Bridging the research gaps on AMR in sub-Saharan Africa – A one health approach
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  1. Rea Kobialka1,
  2. Julius Boniface Okuni2,
  3. Yakhya Dieye3,
  4. Michael Frimpong4,
  5. Olusegun George Ademowo5,
  6. Sheila Makiala6,
  7. Yimtubeznash Woldeamanuel Mulate7,
  8. Kamal Eltom8,
  9. Ahmed Abd El Wahed1,
  10. Annemarie Käsbohrer9,
  11. Damalie Nakanjako10,
  12. Uwe Truyen1
  1. 1Institute of Animal Hygiene and Veterinary Public Health, Germany
  2. 2Veterinary Pharmacy, Clinical and Comparative Medicine, Makerere University, Uganda
  3. 3Institut Pasteur de Dakar, Senegal
  4. 4Kumasi Centre for Collaborative Research in Tropical Medicine, Ghana
  5. 5Institute for Advanced Medical Research and Training, University of Ibadan, Nigeria
  6. 6Institute National Research Biomedical (INRB), Democratic Republic of the Congo
  7. 7Microbiology, Immunology and Parasitology, Addis Ababa University, Ethiopia
  8. 8University of Khartoum, Sudan
  9. 9German Federal Institute for Risk Assessment, Germany
  10. 10College of Health Sciences, Makerere University, Uganda

Abstract

Disease outbreaks and management are a huge challenge for public health systems worldwide. With globalization, spread of pathogens through trade and travel increases the demand for suitable medicines. At the same time, the excessive use of drugs in veterinary and human medicine leads to a reduction in effectiveness and even to the development of resistances. Antimicrobial resistance (AMR) has become a major problem worldwide. While most high-income countries have already developed a strong surveillance system for AMR, low- and middle-income countries have an urgent need for monitoring AMR. This, as well as the coinfection with neglected tropical diseases (NTDs), remains a significant challenge, especially across sub-Saharan Africa.

The aim of this project is to strengthen the capacity across 7 Sub-Saharan African countries for improved management of AMR and NTDs. The focus here lies on identifying the linkages and transmission of AMR between humans, animals and the environment in a One Health context. In order to better control AMR, academic and research institutions from the eight participating countries have developed 6 work packages (WPs) to build the local capacity to identify the main transmission routes.

The WPs include screening for AMR in humans, environment and livestock, employing surveillance and genetic mapping of circulating AMR strains; investigating relationships between helminthic infections and drug resistant bacteria; developing capacities for point of need diagnostics of AMR and NTDs using mobile labs for field application; identifying any changes in antimicrobial use and AMR incidence during the COVID-19 pandemic in Sub-Saharan African contexts; controlling communicable disease transmission, by identifying and improving existing hygienic practices at the human-animal-environment interface; and building capacity for sustainable leadership in antimicrobial stewardship (AMS).

With the established consortium, this project proposes unique solutions for AMR/AMS through the development of both knowledge and technological infrastructure from a large, diverse, multidisciplinary team.

https://doi.org/10.1136/bmjgh-2023-EDC.27

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