In the United States, for major regulations benefit-cost analysis has been required for over 40 years, and distributional analysis has been required for over 30 years. The impacts of these regulations typically range from over $100 million to well over $1 billion (USD) annually. They address public health across numerous policy areas, such as environmental quality and transportation, workplace, and food safety. As the focus of UHC broadens to include interventions outside of the health care system, benefit-cost analysis is likely to be increasingly useful to capture the full range of health and non-health impacts and to understand how these impacts are distributed across the advantaged and disadvantaged. This presentation will discuss what we have learned about the application of benefit-cost analysis and distributional analysis across sectors and the usefulness of the results for decision-making in the U.S., and the implications for the use of these analytic methods globally.