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Original research
Magnitude, temporal trends and inequality in global burden of tracheal, bronchus and lung cancer: findings from the Global Burden of Disease Study 2017
  1. Zhaojun Wang1,
  2. Liu Hu1,
  3. Jin Li2,
  4. Li Wei1,
  5. Junhang Zhang1,
  6. Jun Zhou3
  1. 1 Department of Thoracic Surgery, The Seventh Affiliated Hospital Sun Yat-sen University, Shenzhen, Guangdong, China
  2. 2 Department of Respiratory, The Seventh Affiliated Hospital Sun Yat-sen University, Shenzhen, Guangdong, China
  3. 3 Department of Thoracic and Cardiac surgery, Shenzhen People's Hospital, Shenzhen, Guangdong, China
  1. Correspondence to Dr Jun Zhou; zhoujun11111{at}yeah.net; Professor Junhang Zhang; zhangjunhang1111{at}163.com

Abstract

Introduction We aimed to assess the magnitude, temporal trends and socioeconomic disparity in the global burden of tracheal, bronchus and lung (TBL) from 1990 to 2017, using data extracted from the Global Burden of Diseases study (GBD 2017).

Methods We extracted data from the GBD 2017 study. A series of comparative and descriptive analyses of the disease burden between females and males and countries with different socioeconomic development statuses (Social Demographic Index, SDI). We also analysed the temporal trends of age-standardised disability-adjusted life year rates (ASDR) of TBL cancer at the global and super-regional level by means of joinpoint regression. Finally, we also calculated Concentration Index to explore trends of between-country inequality in cancer burden from 1990 to 2017.

Results During the past 27 years, the global incidence of TBL cancer cases and death cases has increased by 100% and 82.3% respectively, but the increase number was mainly influenced by population growth and ageing. After adjustment, from 1990 to 2017, the ASDR of TBL has increased by 3% and the age-standardised death rate has decreased by 7%. The global TBL cancer burden fell by 15.3%. The joinpoint analysis revealed that the overall trend of age-standardised TBL cancer burden for both females and males significantly changed twice between 1990 and 2017, and it varied across countries with different SDI values and was also different between females and males. Age-standardised TBL cancer burden was more concentrated in higher socioeconomic development countries, but the development of healthy inequality showed a downward trend in males while showing an upward trend in females.

Conclusion The magnitude and temporal trends of TBL cancer burden varied across countries and sex. This study highlighted the importance of crafting health policy to adapt to local conditions to manage the global burden of TBL cancers.

  • public health
http://creativecommons.org/licenses/by-nc/4.0/

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/bmjgh-2020-002788

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    Footnotes

    • Handling editor Sanni Yaya

    • ZW and LH contributed equally.

    • JZ and JZ contributed equally.

    • Contributors ZW wrote the manuscript. JL analysed the data. JZh conceived the study and provided guidance. All other authors contributed to the analysis and reviewed the manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

    • Patient consent for publication Not required.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Data availability statement Data are available in a public, open access repository. All data is publically available. Data are available on request.