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  1. Mosepele Mosepele1,
  2. Cecilia Kanyama2,
  3. David Meya3,
  4. Fiona Cresswell4,5,
  5. Timothee Chammard6,
  6. Henry Mwandumba7,
  7. Graeme Meintjes8,
  8. Godfrey S Mfinanga9,
  9. Chiratidzo Ndhlovu10,
  10. Joseph Jarvis11
  1. 1University of Botswana School of Medicine, Botswana-Harvard AIDS Institute, Botswana
  2. 2University of North Carolina, USA
  3. 3Infectious Disease Institute, Makerere University, Uganda
  4. 4London School of Hygiene and Tropical Medicine, UK
  5. 5Infectious Diseases Institute, Kampala, Uganda
  6. 6Institute Pasteur, Paris, France
  7. 7Malawi-Liverpool Wellcome Trust Research Programme, Lilongwe, Malawi
  8. 8University of Cape Town, South Africa
  9. 9National Institute of Medical Research, Dar es Salaam,Tanzania
  10. 10University of Zimbabwe, Harare, Zimbabwe
  11. 11London School of Hygiene and Tropical Medicine, UK, and Botswana-Harvard AIDS Institute Partnership, Botswana


Background Central nervous system infections, including meningitis, continue to cause significant morbidity in Africa. HIV has contributed to the epidemiology of CNS infections in this setting. Notable advances in the study of CNS infections by several groups have demonstrated the utility of new diagnostic strategies and impact of novel treatment strategies. However, efforts to coordinate meningitis research in Africa, and between Africa and the rest of the world remain very limited.

Methods In a bid to promote a coordinated study of CNS infections across Africa, and in collaboration with other meningitis groups globally, the researchers of the AMBITION study (High Dose Ambisome on a Fluconazole Backbone for Cryptococcal Meningitis Induction Therapy in Sub-saharan Africa: A Randomised Controlled Non-inferiority Trial) are leveraging the EDCTP support for the AMBITION trial to set up an Africa Meningitis Trials Network.

Results The Africa Meningitis Trials Network (AMNET) was launched in Malawi in early 2018. Main achievements since the launch of the network, include an internal review of meningitis research across network sites and launch of the network website. The network also has two study protocols pending ethics review at all sites. These studies will provide much needed information on resources available for meningitis care, research and provide a baseline epidemiology of meningitis in Africa.

Conclusion AMNET provides a rare opportunity for investigators interested in meningitis research to leverage the ongoing AMBITION trial to conduct Africa-wide preliminary research on meningitis. The network is recruiting additional members in Africa and globally to collaborate on meningitis research, and also apply for research funding to support meningitis work. Anyone interested in knowing more about the network should contact the AMNET communications officer, Ms Phum’lani Machao,

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