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ABSTRACTS OF POSTER PRESENTATIONS
PO 8503 EPIDEMIOLOGY, CO-INFECTIONS AND HAEMATOLOGICAL FEATURES OF SCHISTOSOMIASIS IN SCHOOL-AGED CHILDREN LIVING IN LAMBARÉNÉ, GABON
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  1. Jean Claude Dejon Agobe1,
  2. Yabo J Honkpehedji1,
  3. Jeannot Fréjus Zinsou1,
  4. Jean-Ronald Edoa1,
  5. Bayodé R Adegbite1,
  6. Mohamed Duali1,
  7. Fabrice L Mougeni1,
  8. Bertrand Lell1,
  9. Peter G Kremsner2,
  10. Martin P Grobusch3,
  11. Ayola Akim Adegnika1
  1. 1Centre de Recherches Médicales de Lambaréné, Libreville, Gabon
  2. 2Institut für Tropenmedizin, Eberhard Karls Universität Tübingen and German Center for Infection Research (DZIF), Germany
  3. 3Academic Medical Center, University of Amsterdam, the Netherlands

Abstract

Background Schistosomiasis is a highly prevalent parasitic infection in Central Africa, where co-endemicity with other parasitic infections is common, and schistosomiasis outcomes can be affected by those other infections. Therefore, proper schistosomiasis control needs epidemiological data accounting for co-infections, too. In this present study, our objective was to determine the epidemiological situation around schistosomiasis in Lambaréné.

Methods A cross-sectional study was conducted among school-aged children living in Lambaréné. Urine filtration exam was performed for the detection of Schistosoma eggs. Kato-Katz and stool culture (Coproculture and Harada-Mori) techniques were used for the detection of soil-transmitted helminths. Detection of Plasmodium spp. and blood microfilariae was performed applying light microscopy. Risk factors for schistosomiasis and factors associated with schistosomiasis were investigated; haematology parameters evaluated.

Results A total of 614 school children with available schistosomiasis status were included in the analysis. Mean age was 10.9 (SD=2.7) years, with a 0.95 boy-to-girl sex ratio. The prevalence of schistosomiasis was 26%. No risk factors except human-water contact were associated with schistosomiasis. Only Trichuris trichiura co-infection was associated with an increased odd (aOR=2.3, p-value=0.048) to be infected with schistosomiasis. Full blood counts showed a decrease of haemoglobin level and increase of WBC and platelet levels among the schistosoma-infected children. Haematuria was found associated with schistosomiasis (aOR=14.5, p-value<0.001) and was suitable to predict the disease.

Conclusion The prevalence of schistosomiasis is moderate in Lambaréné where human-water contact remains the main risk factor and praziquantel is available for treatment. Trichuriasis is associated with increased risk to be infected. Children with schistosomiasis exhibit a distinct full blood count profile and haematuria is found to be more suitable to predict infection. However, it is desirable to implement comprehensive approaches beyond chemotherapy for schistosomiasis control in this area as recommended by WHO.

https://doi.org/10.1136/bmjgh-2019-EDC.123

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