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  1. Abdoulaye Djimde1,
  2. on behalf of the WANECAM II consortium,
  3. Martin P Grobusch6,
  4. Rella Zoleko Manego4,
  5. Ghyslain Mombo-Ngoma4,
  6. Stephane Picot7,
  7. Issaka Sagara1,
  8. Colin Sutherland8,
  9. Aminatou Kone1,
  10. Ogobara K Doumbo, †1,
  11. Jose Pedro Gil9,
  12. Anders Björkman9,
  13. Steffen Borrmann12,
  14. Issiaka Soulama3,
  15. Bakary Fofana1,
  16. Stephan Duparc11,
  17. Alassane Dicko1,
  18. David Hughes10,
  19. Cornelis Winnips10,
  20. Sodiomon B Sirima2,
  21. Eric Adehossi5,
  22. Jean-Bosco Ouedraogo13,
  23. Laurent Dembele1,
  24. Issaka Zongo3,
  25. Sophie Biguenet11,
  26. Edithe Ilboudo-Sanogo2,
  27. Aminata Fofana3
  1. 1Université des Sciences, des Techniques et des Technologies de Bamako (USTTB), Mali
  2. 2Groupe de Recherche Action en Santé (GRAS), Burkina Faso
  3. 3Institut des Sciences et Techniques (INSTech), Ouagadougou Burkina Faso
  4. 4Centre de Recherches Médicales en Lambaréné (CERMEL), Libreville, Gabon
  5. 5University Abdou Moumouni of Niamey, Niger
  6. 6Academic Medical Center (AMC), Amsterdam, The Netherlands
  7. 7University Lyon 1, France
  8. 8London School of Hygiene and Tropical Medicine, UK
  9. 9Karolinska Institute (KI), Stockholm, Sweden
  10. 10Novartis Pharma AG, Basel, Switzerland
  11. 11Medicines for Malaria Venture (MMV),Geneva, Switzerland
  12. 12Eberhard Karls Universität Tübingen, Germany


Background Despite major progress in the past decade, malaria remains a major public health problem in sub-Saharan Africa. West and Central Africa account for nearly 2/3 of the burden currently attributable to falciparum malaria. Artemisinin-based combination therapies (ACT) are a cornerstone of our strategy for controlling and eventually eliminating malaria. However, reduced responsiveness/resistance to artemisinin derivatives and to ACTs, an increasing problem in South-East Asia is a major concern. It is of utmost importance to develop new antimalarial drugs from novel chemical classes that can replace ACTs. KAF156, an imidazolepiperazine, is a leading candidate in the antimalarial drug development pipeline. Combination of KAF156 with a Solid Dispersion Formulation of lumefantrine (LUM-SDF) is expected to be fast acting, fully curative, improve patient adherence and can potentially reduce malaria transmission.

Methods WANECAM II proposes to advance the clinical development of KAF156 through clinical trials in adults and children, with integrated capacity building and infrastructure development activities. The trial programme will be undertaken in the context of networking, team-building, leadership development and community engagement schemes that will involve intra-European, European-African and intra-African collaborative activities. WANECAM II will accelerate the clinical study of children less than 2 years of age which are the key target for new antimalarial treatments.

Results By the end of the project, the results are expected to contribute to the registration of KAF156/LUM-SDF through stringent regulatory health authorities, increase biomedical research capacity in the consortium and effectively promote networking among the respective teams. A new clinical research team in Niger, a grossly underrepresented country in the African research landscape, will be developed and further increase capacity and infrastructure in the consortium.

Conclusion Providing a new antimalarial drug combination that does not contain an artemisinin derivative and is effective against resistant P. falciparum strains as well as gametocytes and that is likely to be taken in 3 or fewer single doses will be a major advance in the field. The new combination of KAF156 with LUM-SDF is expected to provide such major advance upon successful conclusion of the WANECAM II project.

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