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Delivering comprehensive HIV services across the HIV care continuum: a comparative analysis of survival and progress towards 90-90-90 in rural Malawi
  1. Emily B Wroe1,
  2. Elizabeth L Dunbar1,
  3. Noel Kalanga2,
  4. Luckson Dullie1,
  5. Chiyembekezo Kachimanga1,
  6. Andrew Mganga3,
  7. Michael Herce4,
  8. Jason Beste5,
  9. Jonas Rigodon6,
  10. Lawrence Nazimera7,
  11. Ryan K McBain8
  1. 1Partners In Health, Neno, Malawi
  2. 2Health Systems and Policy, College of Medicine, Blantyre, Malawi
  3. 3Department of HIV and AIDS, Ministry of Health, Lilongwe, Malawi
  4. 4Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
  5. 5Partners In Health, Harper, Liberia
  6. 6Haiti Delegation, American Red Cross, Port-au-Prince, Haiti
  7. 7Ministry of Health, Neno, Malawi
  8. 8Partners In Health, Boston, Massachusetts, USA
  1. Correspondence to Dr Emily B Wroe; emwroe{at}


Introduction Partners In Health and the Malawi Ministry of Health collaborate on comprehensive HIV services in Neno, Malawi, featuring community health workers, interventions addressing social determinants of health and health systems strengthening. We conducted an observational study to describe the HIV care continuum in Neno and to compare facility-level HIV outcomes against health facilities nationally.

Methods We compared facility-level outcomes in Neno (n=13) with all other districts (n=682) from 2013 to 2015 using mixed-effects linear regression modelling. We selected four outcomes that are practically useful and roughly mapped on to the 90-90-90 targets: facility-based HIV screenings relative to population, new antiretroviral therapy (ART)enrolments relative to population, 1-year survival rates and per cent retained in care at 1 year.

Results In 2013, the average number of HIV tests performed, as a per cent of the adult population, was 11.75%, while the average newly enrolled patients was 10.03%. Percent receiving testing increased by 4.23% over 3 years (P<0.001, 95% CI 2.98% to 5.49%), while percent enrolled did not change (P=0.28). These results did not differ between Neno and other districts (P=0.52), despite Neno having a higher proportion of expected patients enrolled. In 2013, the average ART 1-year survival was 80.41% nationally and 91.51% in Neno, which is 11.10% higher (P=0.002, 95% CI 4.13% to 18.07%). One-year survival declined by 1.75% from 2013 to 2015 (P<0.001, 95% CI −2.61% to −0.89%); this was similar in Neno (P=0.83). Facility-level 1-year retention was 85.43% nationally in 2013 (P<0.001, 95% CI 84.2% to 86.62%) and 12.07% higher at 97.50% in Neno (P=0.001, 95% CI 5.08% to19.05%). Retention declined by 2.92% (P<0.001, 95% CI −3.69% to −2.14%) between 2013 and 2015, both nationally and in Neno.

Conclusion The Neno HIV programme demonstrated significantly higher survival and retention rates compared with all other districts in Malawi. Incorporating community health workers, strengthening health systems and addressing social determinants of health within the HIV programme may help Malawi and other countries accelerate progress towards 90-90-90.

  • Hiv
  • health systems

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Key questions

What is already known about this topic?

  • Numerous studies have explored progress towards the Joint United Nations Programme on HIV/AIDS 90-90-90 targets, which could be framed as an HIV-oriented extension of the universal health coverage movement as they focus on quality across the HIV care continuum.

  • However, these studies rely on infrequent and population-based surveys, and there is a need for a more practical approach to programme monitoring.

  • Many studies have advocated for HIV programmes to include comprehensive services, such as community health workers and different forms of psychosocial and economic support, but evaluations of comprehensive programmes with these components are limited.

What are the new findings?

  • Our study suggests that HIV programmes focusing on social determinants of health, community health workers and direct support to ministries of health may increase survival and retention for patients with HIV.

  • We also introduce a practical approach for programme monitoring, using components aligned with the 90-90-90 targets.

Recommendations for policy

  • As governments strive towards achieving the 90-90-90 targets and universal health coverage, it is worth considering policies integrating HIV programming in primary healthcare via support of the public sector and strong community footprints, and adopting approaches that address basic health systems needs and the social determinants of health.


In 2015, the Government of Malawi committed to the Joint United Nations Programme on HIV/AIDS (UNAIDS) goal known as 90-90-90: 90% of HIV-positive patients diagnosed, 90% of those diagnosed sustained on treatment and 90% of those on treatment achieving viral suppression—all by 2020.1 However, robustly measuring progress towards these targets relies on expensive and infrequent population-based surveys, which may not always be practical for local programmes or in routine service delivery settings.2 Given the recognition that achieving 90-90-90 will require a health system strengthening approach involving local governments and civil society partners, there is a need for a more practical, programme-oriented approach for local monitoring.3 The 90-90-90 targets can help programmes measure success and make targeted improvements to HIV services in the spirit of achieving universal health coverage (UHC),4 given the focus on providing high-quality care for every patient with HIV in a given population.

Malawi’s pursuit of 90-90-90 is particularly important given the context: it is one of only nine countries with HIV prevalence exceeding 9%, and in 2015 only half of those affected were receiving treatment—approximately 500 000 people.5 6 As a landlocked, mountainous country with limited supply chains and infrastructure, and having severe resource constraints commensurate with the fourth lowest gross domestic product (GDP) per capita in the world, acquisition and distribution of antiretroviral therapy (ART) to these individuals are highly challenging.7 8 However, Malawi has progressive policies, clear commitment and strong central leadership in the HIV programme: Malawi was the first country to initiate Option B+, placing all HIV-positive pregnant women on ART, regardless of CD4 count.9 In 2016, the national HIV programme adopted the WHO recommendations for universal treatment.10 One study by Medecins sans Frontieres in Chiradzulu District in southern Malawi showed that a high level of population viral suppression is possible in this setting.11

Working towards 90-90-90 targets requires both national commitment as well as innovation in service delivery. Throughout the AIDS epidemic, multiple approaches and debates have been advanced as a means to achieve ART coverage and epidemic control, including those highlighting the tension between HIV integration within primary care versus more vertical HIV interventions, and facility-oriented versus community-oriented models.12 For the latter, many community-based programmes have used community health workers (CHWs) to increase retention in care for HIV-positive adults and children and HIV-exposed infants.13–17 In addition, economic support to offset treatment costs and address underlying poverty has been put forward in the form of cash transfers, and programmes including food packages have shown higher rates of adherence.18–21 Since 2007, Partners In Health (PIH) and the Malawi Ministry of Health (MOH) have been collaborating in one of the country’s poorest districts—Neno District—to implement an innovative HIV/AIDS service delivery model, grounded in decentralised care and a strong community footprint.22–24 This programme is founded on a long history of PIH’s work in partnership with governments and communities globally.12 25 26 An extensive literature demonstrates that a community-based service delivery platform employing CHWs is effective in providing patients with psychosocial accompaniment, adherence support, longitudinal follow-up and missed visit tracking.27–30 It also addresses social determinants of disease—meaning social and economic conditions that can influence differences in health status—as part of a comprehensive package.27 28 Furthermore, to promote sustainability, the model is integrated within the Malawi MOH systems to strengthen primary healthcare, an approach that has also been used in Haiti and Rwanda.12 25

In this manuscript, we characterise the HIV care continuum in Neno District, and compare facility-level HIV outcomes between the Neno programme and all other health facilities nationally to estimate impact. Specifically, we describe programme performance over a 3-year period (2013–2015) according to the 90-90-90-aligned outcomes along the HIV care continuum, comparing outcomes from Neno District facilities with all other Malawian facilities. We describe the results for HIV screening, enrolment, retention and survival, describing outcomes over time to interrogate consistency and robustness of observed effects to secular trends. We also describe our programme practices and interventions, which encompass establishing a strong community footprint, addressing the social determinants of health and advancing true partnerships with the public sector.


Setting and study population

Since 2007, the Malawi MOH in collaboration with PIH—known locally as Abwenzi Pa Za Umoyo—have instituted a novel, community-based HIV care programme in Neno District. Neno District covers a catchment area of 1469 km2 in Malawi’s south-west zone and is home to an estimated 150 841 people in 2015.31 It represents one of the poorest and most rural districts in the country, with no tarmac roads, the majority of the population relying on subsistence agriculture and only 3.7% having electricity.32

For our study, we included all 13 health facilities in Neno District, including 1 district hospital, 1 community hospital and 11 primary health centres, all of which have been providing free HIV care since 2011. For the comparative analysis, we included all facilities in Malawi providing HIV care, comprising 29 districts and 682 facilities—which, including Neno, represents over 4 800 000 HIV screening events and 370 000 new ART enrolments. In Malawi, 84% of the population is rural.31

Neno HIV programme design

The novelty of the Neno District HIV programme resides in three core principles, each rooted in the concept of accompaniment—or supporting the entirety of needs of the patient—with a focus on delivering services in a community-oriented way with the intention to reduce structural barriers to successful treatment:

  1. A strong community footprint: A network of 900 paid, trained and mentored CHWs, living in the communities they serve, work with 6–10 patients with HIV, on average, focusing on psychosocial support, promotion of ART adherence and side effect monitoring, and tracking and accompanying clients to facilities. The CHWs act as ‘foot soldiers’ to the MOH cadre of health surveillance assistants (HSA), who have higher population coverage (1 HSA per roughly 1775 population vs 1 CHW per 168) and broader job descriptions.33 The community activities also feature a community support initiative that provides community-based psychosocial support through support groups for those affected by HIV.

  2. A focus on social determinants of health:  A socioeconomic assessment is performed for each patient in order to determine their level of poverty and specific needs. This assessment enables microeconomic interventions for vulnerable patients in the forms of non-conditional cash transfer, payment of school fees for children and addressing housing needs. In 2015, approximately 15% of ART patients received direct assistance such as cash transfers (average US$23.3), with an additional 30% receiving indirect assistance such as school or vocational support (average US$10.9). Additionally, a nutrition support programme provides food packages for a period of 4 months to all patients initiating ART.

  3. Partnership with the MOH to strengthen primary and secondary healthcare systems: MOH and PIH leadership, both based permanently in Neno District, work together to identify needs and fill gaps, with PIH employing a broad-based health systems strengthening approach. For example, PIH employs clinical staff for daily direct care delivery jointly supervised with MOH: in 2015 approximately one-third of clinical staff in Neno were employed by PIH. In addition, PIH helps construct and maintain infrastructure and acts as a backstop for essential medicines. Additionally, PIH supports a district-wide electronic medical record (EMR) system that collects patient-level clinical details and triggers a process for tracking clients who miss an appointment.

Data collection

The central MOH aggregates HIV data from all health facilities providing HIV care throughout Malawi on a quarterly basis, including Neno District. We chose a study period from Q1 2013 to Q4 of 2015, for several reasons: (1) this represented the broadest time range for which data were available for all facilities in Neno; (2) indications for ART initiation were constant; and (3) because the number of ART-providing facilities nationally had stabilised following substantial decentralisation in 2011 and 2012 following introduction of Option B+.

During 2013–2015, national policy mandated all HIV-positive patients with CD4 ≤500 cells/mm3 or WHO stage 3 or 4 (regardless of CD4 count) be enrolled in ART, in addition to all HIV-positive pregnant women and children under 5 years confirmed HIV-positive.34 Thus, the following were the study inclusion criteria: (1) a positive diagnosis of HIV and (2) enrolment in the national ART programme between 1 January 2013 and 30 December 2015. All facilities outside Neno providing HIV care in Malawi during this time period were chosen as comparison facilities. Fidelity to enrolment protocols and quality of data were monitored both centrally during quarterly MOH supervision at the facility level and through routine data validation.35


We developed HIV programme performance metrics aligned with the UNAIDS 90-90-90 targets36 that evaluated finding, enrolling and achieving high-quality outcomes in both known and undiagnosed expected patients with HIV in a given adult population. Thus, for case finding, we evaluated the number of total HIV tests performed in a district for those aged >15 years, over the course of a year, represented as relative to the number of individuals over the age of 15 in the catchment area. For successful enrolments, we measured the per cent of the catchment population newly enrolled in HIV care on an annual basis among those expected to be HIV-positive based on district population prevalence.37

For both metrics, the number of new screenings and new enrollees was selected, rather than cumulative total, in order to measure district-level improvement in the care continuum over time. However, in districts that were closer to achieving these targets at baseline, it is likely that screenings and enrolments decelerate—as new HIV-positive individuals become harder to find and enrol. Thus, we also report on the proportion achieved for anticipated full enrolment and the yield of HIV testing for Neno and nationally. We used the highest estimate of 1 100 000 expected people living with HIV (PLHIV) in Malawi in 2015 and applied district-level HIV prevalence estimates from the 2015–2016 Demographics and Health Survey.32

For the quality and success of treatment, in place of viral suppression used for the third 90, we elected to measure the average 1-year survival and retention rates at the facility level within districts. In many sub-Saharan African contexts, including Malawi, viral load results are not routinely available—largely because this depends on testing and supply chain systems for which a majority of facilities are not yet equipped. This limitation in routine viral load results includes Neno until system improvements and GeneXpert testing were introduced in late 2016. In such contexts, quality of care can be more broadly assessed in terms of patient survivorship and their routine return to facilities to acquire medicines to continue treatment.

Statistical analysis

We examined statistical power to detect a medium effect size (δ=0.50) when comparing facility-level trends within Neno district versus all facilities throughout all other districts, over a 3-year period. Assuming a standard α level of 0.05, a sample of 682 facilities, intracluster correlation coefficient for district-level clustering of <0.05 and serial correlation of r=0.50, statistical power was greater than 80% to detect the effect size of interest.

We used mixed-effects, multilevel models to evaluate HIV outcomes across districts and to compare performance in Neno District versus all other districts. Random effects were incorporated for facilities and districts, whereby facilities were nested within districts and districts were nested within years. Fixed effects were included for Neno District and for specific years, in order to examine change in 2014 and 2015, relative to the baseline year of 2013. The interaction term of interest was Neno × year, which examined whether change over time on outcomes of interest was greater in Neno District compared with other districts. As a secondary set of analyses, we incorporated two sets of demographic district-level covariates: namely, the percentage of individuals in the district who are female and the percentage of households with electricity—as a proxy for district-level wealth, taken from the 2015–2016 Demographics and Health Survey.32 Neither covariate had any substantive impact on the results. We therefore chose to report primary models throughout in order to aid interpretability. Analyses were conducted in STATA V.13.0 SE.

Patient involvement

This was an observational study, and patients were not involved in the study design.


Descriptive characteristics of sample

From January 2013 through December 2015, 4 869 503 screenings for HIV were performed at facilities throughout Malawi. Over this same period, 368 046 individuals aged 15 and over were newly enrolled in the HIV programme. The average 1-year survival among new ART enrollees at the facility level was 79.5%, and the per cent retained in care at 1 year was 83.9%. Table 1 presents an overview of this information at the district level on an annual basis.

Table 1

Average annual facility-level outcomes, by district (2013–2015)

Performance over time

Case finding

At baseline in 2013, the estimated proportion of the adult population who underwent HIV testing at a health facility was 11.75% (P<0.001, 95% CI 10.53% to 12.96%). This was 3.94% higher in Neno District (15.69%), but the difference was not statistically significant (P=0.24, 95% CI −2.61% to 10.49%). Over the 3-year period, the average per cent of the population in all districts receiving HIV screening increased by 4.23% (P<0.001, 95% CI 2.98% to 5.49%). This trend towards improvement over time was not significantly different in Neno (P=0.52, 95% CI −8.98% to 4.52). The yield of HIV testing in Neno was different from the yield nationally: Over the 3-year period, the national positivity rate among screenings was 6.91% (P<0.001, 95% CI 5.84% to 7.98%); this was 1.35% lower in Neno District (P=0.01, 95% CI −2.42% to −0.29%). Table 2 shows these outcomes by district over the 3-year period.


In 2013, the average per cent of total expected HIV-positive adults (ages 15 and over) who were newly enrolled in ART during that year—based on national HIV prevalence—was 12.42% (P<0.001, 95% CI 10.54% to 14.30%). New enrolment levels were not significantly higher in Neno District (P=0.56, 95% CI −13.12% to 7.13%). From 2013 to 2015, annual enrolment levels did not change nationally (P=0.17, 95% CI −0.22% to 1.74%). This trend was similar in Neno District (P=0.78, 95% CI −3.42% to 4.56%). Table 2 shows the breakdown of these trends. However, progress towards total enrolment in Neno District exceeds the national average, and as of December 2015 Neno had enrolled 62.1% (n=7332 of n=11 800) of the expected total district population of persons living with HIV, while nationally this was 54.7% (n=563 203 of n=1 028 814) (P<0.001).32 38

Table 2

Average annual facility-level outcomes, by district, by year (screening and enrolment)


At baseline, 1-year survival among those in quarterly cohorts was 80.41% (P<0.001, 95% CI 79.22% to 81.59%) across facilities within districts. Comparatively, survival was 11.10% higher in Neno District, at 91.51% (P=0.002, 95% CI 4.13% to 18.07%). Between 2013 and 2015, survival rates declined by 1.75% (P<0.001, 95% CI −2.61% to −0.89%). This was not significantly different in Neno District (P=0.83, 95% CI −6.60% to 5.33%) (table 3).

Table 3

Average annual facility-level outcomes, by district, by year (survival and retention)


In 2013, 1-year retention among quarterly cohorts was 85.43% across all facilities within districts (P<0.001, 95% CI 84.2% to 86.62%). In Neno, this figure was 12.07% higher at 97.50% (P=0.001, 95% CI 5.08% to 19.05%). From 2013 to 2015, retention levels declined nationally by 2.92% (P<0.001, 95% CI −3.69% to −2.14%). This trend was similar in Neno (P=0.98, 95% CI −5.34% to 5.50%). Figure 1 provides an overview of results for survival and retention outcomes, and table 3 provides these outcomes by year.

Figure 1

One-year survival and retention among newly enrolled patients with HIV, 2013–2015.


We observed high total enrolment and 1-year survival and retention in care for ART-treated patients in Neno District, higher than all other districts nationally, suggesting the effectiveness of the Neno HIV programme across the HIV care continuum. These results were robust to secular trends and persisted over the entire 2013–2015 study period. While this study is not designed to estimate the relative impact of the components of our model, we postulate that a few unique aspects about the Neno HIV programme play critical roles in the results observed. First, the trained and paid cadre of CHWs enjoy low patient volume per CHW, allowing CHWs to do frequent routine—often daily—visits to support patient adherence, trace patients who missed visits, identify side effects or ill patients early, and flag any specific issues for the clinical staff. This is supported by literature advocating for CHWs for HIV programmes.14 15 27 29 39 This CHW system is backed up by a robust standard operating procedure for missed visit tracking: CHWs make up the first tier, and when that fails HIV clinic staff go out on motorbikes on a weekly basis to locate patients and bring them back to clinic where possible.

Second, given the impoverished population served, we posit that our focus on addressing social determinants of health is a critical piece, including the provision of food packages, cash transfers and inkind support to ART patients. Numerous studies support food packages as a means to optimising patient adherence.19–21 Additionally, as governments work towards UHC, finding mechanisms to reduce catastrophic health expenditures is important,4 with Neno District highlighting the use of social welfare interventions to mitigate the effects of poverty on our patients. Third, the approach in Neno District is characterised by the comprehensive spectrum of support by PIH, with a long-term commitment to key system inputs beyond technical assistance or capacity building. For example, as of 2016, PIH employs 34% of clinical staff doing direct care delivery and 66% of HIV programme staff, which has been consistent since 2013.40 Other examples include construction and maintenance of hospitals and clinics, backstopping the MOH formulary with procurement of essential medications and health commodities, supporting an EMR and data quality improvement initiatives, and purchasing critical medical equipment for the district. This approach is informed by and echoes the sentiments put forward in the global arena, such as the Declaration of Alma Ata, advocating for primary healthcare and the 2005 Paris Declaration on Aid Effectiveness on aligning aid to countries’ priorities and local systems.41 42

We also describe favourable population-level uptake of HIV screening and ART linkage in Neno District. While the annual number of ART enrolments observed in Neno is consistent with national trends, Neno District is farther along towards achieving full programme enrolment. As districts in Malawi strive towards complete case finding, the yield of HIV testing in identifying new infections will decrease over time, and programmes will have to do more HIV testing and/or more targeted HIV testing to find new patients. These trends may have important considerations for programme design, in that traditionally ‘high yield’ has been a benchmarker for successful HIV testing programmes, but as countries move towards achieving the first 90, lower yields may in fact be a natural marker of success. This highlights the need for innovative and data-driven testing strategies to reach underserved PLHIV who do not yet know their status and who are being missed by more traditional facility-based testing strategies. The approach in Neno has been to operationalise HIV testing as a standard screening test at the community, outpatient department and inpatient levels, which in 2015–2016 had yields of 1.9%, 2.9% and 3.8%, respectively.43 In addition to striving towards universal opt-out, inpatient testing services, Neno employs a programme called Screening for Health And Referral in the Community, an integrated screening programme that targets the most remote areas of the district, sending teams out twice weekly to screen community members for HIV, tuberculosis, malnutrition, hypertension and diabetes. Although the yield is smaller, this blanket approach could be a critical part to reaching full enrolment. Early experience shows that 22.7% of community members screened at these events had never previously been tested.44

The scalability and sustainability of this programme are contingent on a variety of factors. One of the most significant constraints is financing to support this model, as Malawi is one of the poorest countries in the world.7 We have published elsewhere on the cost-effectiveness of this model,45 showing that a quality-adjusted life year gained—on average—from the model costs less than three times the GDP per capita, a traditional marker of cost-effectiveness.46 Beyond cost considerations are additional questions of scalability. In support of the scale-up enterprise, PIH has successfully expanded components of care models to regional and national levels in Rwanda25 and Lesotho.26 Findings reported in this study have also been presented to members of the parliament in Malawi, as well as members of the MOH. In the near term, our goal is to continue monitoring and demonstrating the success of this model and to engage in further health policy discussions.

There are a few key limitations to this study. First, district-level demographic covariates, such as age and gender distribution, were not included in the model as the analysis was done with national-level aggregate data, and HIV survival data were not disaggregated in Malawi by age and gender. Second, the outcomes do not map precisely on to the 90-90-90 targets, both because evaluating programmes by the first 90 without population-level data is challenging and because of the lack of complete viral load data for the district cohorts. As viral load testing becomes more routine and accessible, this will be a critical part of programme evaluation moving forward. We instead opted for a more practical and programme-oriented approach that uses robust proxy outcomes of survival and care retention to evaluate the programme and understand progress on themes of UHC and quality of care. Our analytical approach can be replicated in other resource-limited, high-burden settings to more regularly and rapidly assess HIV programme progress against national targets. Finally, given the retrospective nature of the data, as well as the utilisation of facility-level and district-level data instead of patient-level outcomes, we are limited in our ability to isolate the effect of certain programme components.

This study describes the results of an innovative model of district-wide partnership and HIV service delivery in Neno, demonstrating greater progress towards full HIV programme enrolment and higher 1-year patient retention and survival than national averages. Importantly, these effects have been maintained over at least a 3-year period. As governments strive towards meeting the 90-90-90 targets, we advocate for policies and practices (1) rooted in primary healthcare that tackle comprehensive and basic health system needs; (2) that leverage strong district-level partnership between non-governmental organisations and the public sector; (3) focused on strong community footprints; and 4) that pragmatically address the social determinants of health.


There are numerous people who have contributed to the success of the HIV program in Neno District: former DHOs Felix Chingoli & Jones Masiye; former PIH Malawi Executive Director Keith Joseph; MOH ART Coordinators Finala Phiri; CHW Program Manager Henry Makungwa; POSER Program Manager Victor Kanyema; Community Programs Manager Sam Njolomole; former PIH HIV & Nutrition Program Manager Blessings Banda; current PIH HIV Manager Kondwani Nyangulu; the rest of the numerous MOH and PIH HIV program staff who work tirelessly to bring high quality HIV care to patients who need it most; and lastly all of our CHWs and our HIV patients who help us improve the program, best meet needs, and continue to strive for the best HIV outcomes possible in Neno District.


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  • Handling editor Sanni Yaya

  • Contributors EBW, NK and ELD conceptualised the study. ELD, RKM and AM provided data curation and expertise, and RKM led data analysis and methodology. EBW, NK, LD, CK and LN provided programme contextualisation. MH, JB and JR provided additional technical expertise. EBW and RKM prepared the first draft of the manuscript, and all authors edited and reviewed the manuscript.

  • Funding HIV programme activities in Neno District are funded by private charity donors to Partners In Health.

  • Competing interests None declared.

  • Ethics approval We obtained IRB approval from Malawi’s National Health Science Research Committee based in Lilongwe, Malawi, as well as Partners Healthcare Institutional Review Board in Boston, Massachusetts, USA. As no data were collected at the patient level, this study was exempt from full review.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement All authors had full access to all of the data in the study and can take responsibility for the integrity of the data and the accuracy of the data analysis. Full data set and statistical code can be requested from the corresponding author at Aggregate facility-level data were used, and no patient-level data were part of this study.