User profiles for N. Chegou

Novel N Chegou

Research Scientist (Professor) at Stellenbosch University
Verified email at sun.ac.za
Cited by 5342

Tuberculosis: advances and challenges in development of new diagnostics and biomarkers

…, M Bates, TD McHugh, NN Chegou… - The Lancet Infectious …, 2018 - thelancet.com
Tuberculosis remains the leading cause of death from an infectious disease worldwide. Early
and accurate diagnosis and detection of drug-sensitive and drug-resistant tuberculosis is …

Beyond the IFN-γ horizon: biomarkers for immunodiagnosis of infection with Mycobacterium tuberculosis

NN Chegou, J Heyckendorf, G Walzl… - European …, 2014 - Eur Respiratory Soc
Latent infection with Mycobacterium tuberculosis (LTBI) is defined by the presence of M.
tuberculosis-specific immunity in the absence of active tuberculosis. LTBI is detected using …

Tuberculosis assays: past, present and future

NN Chegou, KGP Hoek, M Kriel… - Expert review of anti …, 2011 - Taylor & Francis
Recent developments in the field of TB diagnostics, including the introduction of the Xpert
MTB/RIF assay in field testing, raise the hope for faster and more accurate identification of …

[HTML][HTML] Host markers in QuantiFERON supernatants differentiate active TB from latent TB infection: preliminary report

NN Chegou, GF Black, M Kidd, PD Van Helden… - BMC pulmonary …, 2009 - Springer
Background Interferon gamma release assays, including the QuantiFERON ® TB Gold In
Tube (QFT) have been shown to be accurate in diagnosing Mycobacterium tuberculosis …

Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs …

NN Chegou, JS Sutherland, S Malherbe, AC Crampin… - Thorax, 2016 - thorax.bmj.com
Background User-friendly, rapid, inexpensive yet accurate TB diagnostic tools are urgently
needed at points of care in resource-limited settings. We investigated host biomarkers …

[HTML][HTML] Host blood RNA signatures predict the outcome of tuberculosis treatment

…, DE Zak, N Du Plessis, AG Loxton, NN Chegou… - Tuberculosis, 2017 - Elsevier
… adjust base calls with phred scores <5 to ‘N’ and remove read pairs for which either end has
… : a b u n d a n c e j = log 2 ( c o u n t s j + 1 ) − ∑ r ∈ r e f s log 2 ( c o u n t s r + 1 ) N r e f s …

Hypercytokinaemia accompanies HIV–tuberculosis immune reconstitution inflammatory syndrome

…, K Matthews, R Seldon, NN Chegou… - European …, 2011 - Eur Respiratory Soc
Increased access to combination antiretroviral therapy in areas co-endemic for tuberculosis (TB)
and HIV-1 infection is associated with an increased incidence of immune reconstitution …

[HTML][HTML] RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response

…, SC Mendelsohn, S Suliman, NN Chegou… - Scientific reports, 2020 - nature.com
Improved tuberculosis diagnostics and tools for monitoring treatment response are urgently
needed. We developed a robust and simple, PCR-based host-blood transcriptomic signature…

High level of discordant IGRA results in HIV-infected adults and children

…, AC Hesseling, NN Chegou… - … of Tuberculosis and …, 2008 - ingentaconnect.com
SETTING: Tygerberg district, Western Cape Province, South Africa.OBJECTIVE: To measure
the agreement of two interferon-gamma release assays (IGRAs) and the tuberculin skin test …

[HTML][HTML] Identification of novel host biomarkers in plasma as candidates for the immunodiagnosis of tuberculosis disease and monitoring of tuberculosis treatment …

…, K Stanley, G Van Der Spuy, G Walzl, NN Chegou - Oncotarget, 2016 - ncbi.nlm.nih.gov
There is an urgent need for new tools for the rapid diagnosis of tuberculosis disease. We
evaluated the potentials of 74 host markers as biomarkers for the immunological diagnosis of …