User profiles for N. Chegou
Novel N ChegouResearch Scientist (Professor) at Stellenbosch University Verified email at sun.ac.za Cited by 5342 |
Tuberculosis: advances and challenges in development of new diagnostics and biomarkers
Tuberculosis remains the leading cause of death from an infectious disease worldwide. Early
and accurate diagnosis and detection of drug-sensitive and drug-resistant tuberculosis is …
and accurate diagnosis and detection of drug-sensitive and drug-resistant tuberculosis is …
Beyond the IFN-γ horizon: biomarkers for immunodiagnosis of infection with Mycobacterium tuberculosis
Latent infection with Mycobacterium tuberculosis (LTBI) is defined by the presence of M.
tuberculosis-specific immunity in the absence of active tuberculosis. LTBI is detected using …
tuberculosis-specific immunity in the absence of active tuberculosis. LTBI is detected using …
Tuberculosis assays: past, present and future
Recent developments in the field of TB diagnostics, including the introduction of the Xpert
MTB/RIF assay in field testing, raise the hope for faster and more accurate identification of …
MTB/RIF assay in field testing, raise the hope for faster and more accurate identification of …
[HTML][HTML] Host markers in QuantiFERON supernatants differentiate active TB from latent TB infection: preliminary report
Background Interferon gamma release assays, including the QuantiFERON ® TB Gold In
Tube (QFT) have been shown to be accurate in diagnosing Mycobacterium tuberculosis …
Tube (QFT) have been shown to be accurate in diagnosing Mycobacterium tuberculosis …
Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs …
Background User-friendly, rapid, inexpensive yet accurate TB diagnostic tools are urgently
needed at points of care in resource-limited settings. We investigated host biomarkers …
needed at points of care in resource-limited settings. We investigated host biomarkers …
[HTML][HTML] Host blood RNA signatures predict the outcome of tuberculosis treatment
… adjust base calls with phred scores <5 to ‘N’ and remove read pairs for which either end has
… : a b u n d a n c e j = log 2 ( c o u n t s j + 1 ) − ∑ r ∈ r e f s log 2 ( c o u n t s r + 1 ) N r e f s …
… : a b u n d a n c e j = log 2 ( c o u n t s j + 1 ) − ∑ r ∈ r e f s log 2 ( c o u n t s r + 1 ) N r e f s …
Hypercytokinaemia accompanies HIV–tuberculosis immune reconstitution inflammatory syndrome
…, K Matthews, R Seldon, NN Chegou… - European …, 2011 - Eur Respiratory Soc
Increased access to combination antiretroviral therapy in areas co-endemic for tuberculosis (TB)
and HIV-1 infection is associated with an increased incidence of immune reconstitution …
and HIV-1 infection is associated with an increased incidence of immune reconstitution …
[HTML][HTML] RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response
Improved tuberculosis diagnostics and tools for monitoring treatment response are urgently
needed. We developed a robust and simple, PCR-based host-blood transcriptomic signature…
needed. We developed a robust and simple, PCR-based host-blood transcriptomic signature…
High level of discordant IGRA results in HIV-infected adults and children
…, AC Hesseling, NN Chegou… - … of Tuberculosis and …, 2008 - ingentaconnect.com
SETTING: Tygerberg district, Western Cape Province, South Africa.OBJECTIVE: To measure
the agreement of two interferon-gamma release assays (IGRAs) and the tuberculin skin test …
the agreement of two interferon-gamma release assays (IGRAs) and the tuberculin skin test …
[HTML][HTML] Identification of novel host biomarkers in plasma as candidates for the immunodiagnosis of tuberculosis disease and monitoring of tuberculosis treatment …
There is an urgent need for new tools for the rapid diagnosis of tuberculosis disease. We
evaluated the potentials of 74 host markers as biomarkers for the immunological diagnosis of …
evaluated the potentials of 74 host markers as biomarkers for the immunological diagnosis of …