Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor

K Tatemoto, M Hosoya, Y Habata, R Fujii… - Biochemical and …, 1998 - Elsevier
… amino acid sequence of bovine preproapelin were capable of specifically promoting the
acidification rate in the cells expressing the APJ receptor in a range from 10 7 to 10 10 M, …

Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40

…, M Kobayashi, R Fujii, S Fukusumi, K Ogi, M Hosoya… - Nature, 2003 - nature.com
Diabetes, a disease in which carbohydrate and lipid metabolism are regulated improperly by
insulin, is a serious worldwide health issue 1 , 2 . Insulin is secreted from pancreatic β cells …

[HTML][HTML] AG protein-coupled receptor responsive to bile acids

…, M Hosoya, M Harada, H Yoshida, M Miwa… - Journal of Biological …, 2003 - ASBMB
mm 3-… m) for 4 min in the presence of 1 mm3-isobutyl-1-methylxanthine. THP-TGR5 or
THP-1 cells (1 × 10 5 cells) were treated with bile acids (50 μm) for 20 min in the presence of 1 mm

Henoch-Schönlein purpura nephritis in childhood: pathogenesis, prognostic factors and treatment

…, Y Suzuki, K Suyama, J Suzuki, M Hosoya - Fukushima journal of …, 2013 - jstage.jst.go.jp
… Endo M, Ohi H, Ohsawa I, Fujita T, Matsushita M. Complement activation through the lectin
… Ohara S, Kawasaki Y, Matsuura H, Oikawa T, Suyama K, Hosoya M. Successful therapy with …

A prolactin-releasing peptide in the brain

S Hinuma, Y Habata, R Fujii, Y Kawamata, M Hosoya… - Nature, 1998 - nature.com
… We boiled bovine hypothalamic tissue (2 kg), homogenized it in 1 M acetic acid, and collected
the supernatant. We fractionated the supernatant on a C 18 open column (PrepC 18 125Å:…

[HTML][HTML] Molecular and functional characteristics of APJ: tissue distribution of mRNA and interaction with the endogenous ligand apelin

M Hosoya, Y Kawamata, S Fukusumi, R Fujii… - Journal of Biological …, 2000 - ASBMB
… μm primers, 1.25 units of ExTaq DNA polymerase (Takara Shuzo, Kyoto, Japan) treated with
TaqStart antibody (CLONTECH), 0.1 mm dNTPs… diluted cDNAs, 0.2 μm primers, 1.25 units of …

New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals

…, S Fukusumi, N Iijima, Y Matsumoto, M Hosoya… - Nature cell …, 2000 - nature.com
Only a few RFamide peptides have been identified in mammals, although they have been
abundantly found in invertebrates. Here we report the identification of a human gene that …

[HTML][HTML] Molecular properties of apelin: tissue distribution and receptor binding

Y Kawamata, Y Habata, S Fukusumi, M Hosoya… - … et Biophysica Acta (BBA …, 2001 - Elsevier
We analyzed the tissue distribution of apelin mRNA in rats by a quantitative reverse
transcription-polymerase chain reaction and that of immunoreactive apelin (ir-apelin) by an enzyme …

Comprehensive survey results of childhood thyroid ultrasound examinations in Fukushima in the first four years after the Fukushima Daiichi Nuclear Power Plant …

…, H Takahashi, A Ohtsuru, A Sakai, M Hosoya… - Thyroid, 2016 - liebertpub.com
Background: Thyroid nodules and cancers are rare in children compared with adults. However,
after the 1986 Chernobyl Nuclear Power Plant accident, a rapid increase in childhood …

Olivine-type cathodes: Achievements and problems

A Yamada, M Hosoya, SC Chung, Y Kudo… - Journal of Power …, 2003 - Elsevier
… The P tet –O–M oct linkage in the structure induces the superexchange interaction that
tunes the M 3+ /M 2+ redox energy to useful levels (3.4, 4.1, and 4.8 V for Fe 3+ /Fe 2+ , Mn 3+ /…