In the past decade, leptospirosis has emerged as a globally important infectious disease. It
occurs in urban environments of industrialised and developing countries, as well as in rural …

Human T-lymphotropic virus 1 (HTLV-1) has infected human beings for thousands of years,
but knowledge about the infection and its pathogenesis is only recently emerging. The virus …

… The electronic literature search was updated on August 2012. The results were limited in
the search string to articles published from 1960 to August 2012 and to English, Spanish, …

Background Global control of tuberculosis is hampered by slow, insensitive diagnostic
methods, particularly for the detection of drug-resistant forms and in patients with human …

Background The Xpert MTB/RIF test (Cepheid, Sunnyvale, CA, USA) can detect tuberculosis
and its multidrug-resistant form with very high sensitivity and specificity in controlled studies, …

Background Bedaquiline (Sirturo, TMC207), a diarylquinoline that inhibits mycobacterial ATP
synthase, has been associated with accelerated sputum-culture conversion in patients with …

Background: Raltegravir is an HIV-1 integrase strand-transfer inhibitor with potent in vitro
activity. This study explored the antiretroviral activity and safety of raltegravir in treatment-naive …

The hyperinfection syndrome (HS) caused by Strongyloides stercoralis has a high mortality
rate (15% to 87%). A variety of risk factors and predisposing conditions have been described, …

Caspofungin is a new broad-spectrum antifungal drug. A multicenter, double-blind, randomized
trial was conducted to assess the efficacy, safety, and tolerability of caspofungin relative …

… MD a , Eduardo Gotuzzo MD b , Eduardo G Arathoon MD c , L.Miguel Noriega MD d , Nicholas
A Kartsonis MD e , Robert J Lupinacci MS e , Juanita M Smietana e , Mark J DiNubile MD …