The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates
…, D Foster, RE Higgs, D Balasubramaniam… - Science translational …, 2021 - science.org
… constant; k d , dissociation kinetic rate constant; K d , binding … d ) values in the picomolar
range and the remaining 47% had apparent K d values in the nanomolar range, with a mean K d …
range and the remaining 47% had apparent K d values in the nanomolar range, with a mean K d …
Hydrogen-exchange mass spectrometry for the study of intrinsic disorder in proteins
D Balasubramaniam, EA Komives - … et Biophysica Acta (BBA)-Proteins and …, 2013 - Elsevier
… amide group has exchanged with solvent deuterium when the sample is incubated in 2 H 2
O (D 2 O). H/D exchange analysis can be performed on intact proteins [28], [29], however it is …
O (D 2 O). H/D exchange analysis can be performed on intact proteins [28], [29], however it is …
A dynamic and intricate regulatory network determines Pseudomonas aeruginosa virulence
D Balasubramanian, L Schneper, H Kumari… - Nucleic acids …, 2013 - academic.oup.com
… The exopolysaccharide alginate is a linear polymer of β-d-mannuronic acid and α-l-guluronic
acid (185), which stimulates production of IgG and IgA antibodies (186). Although …
acid (185), which stimulates production of IgG and IgA antibodies (186). Although …
Controlling software architecture erosion: A survey
L De Silva, D Balasubramaniam - Journal of Systems and Software, 2012 - Elsevier
Software architectures capture the most significant properties and design constraints of
software systems. Thus, modifications to a system that violate its architectural principles can …
software systems. Thus, modifications to a system that violate its architectural principles can …
Staphylococcus aureus pathogenesis in diverse host environments
D Balasubramanian, L Harper, B Shopsin… - Pathogens and …, 2017 - academic.oup.com
Staphylococcus aureus is an eminent human pathogen that can colonize the human host
and cause severe life-threatening illnesses. This bacterium can reside in and infect a wide …
and cause severe life-threatening illnesses. This bacterium can reside in and infect a wide …
LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection
…, BA Heinz, D Foster, RE Higgs, D Balasubramaniam… - BioRxiv, 2020 - biorxiv.org
… Viral replication and viral loads were assessed in lung tissue (B, D) h arvested on Day 6.
AC: Values represent the mean and standard error of the mean for 3 or 4 animals. D: bars …
AC: Values represent the mean and standard error of the mean for 3 or 4 animals. D: bars …
YidC assists the stepwise and stochastic folding of membrane proteins
T Serdiuk, D Balasubramaniam, J Sugihara… - Nature chemical …, 2016 - nature.com
… After partial unfolding as in a, we brought the AFM stylus close to the membrane surface (d
~10–15 nm) to relax the unfolded polypeptide (left schematic). After a refolding time of 2 s (…
~10–15 nm) to relax the unfolded polypeptide (left schematic). After a refolding time of 2 s (…
Application of the Internet of Things in 3E (efficiency, economy, and environment) factor-based energy management as smart and sustainable strategy
…, XP Nguyen, D Balasubramaniam… - Energy Sources, Part …, 2021 - Taylor & Francis
Energy plays an important role in economic growth and environmental protection, is an
important input of many manufacturing industries, and one of the essential commodities of …
important input of many manufacturing industries, and one of the essential commodities of …
[HTML][HTML] An anti-ANGPTL3/8 antibody decreases circulating triglycerides by binding to a LPL-inhibitory leucine zipper-like motif
D Balasubramaniam, O Schroeder, AM Russell… - Journal of Lipid …, 2022 - ASBMB
Triglycerides (TG) are required for fatty acid transport and storage and are essential for
human health. Angiopoietin-like-protein 8 (ANGPTL8) has previously been shown to form a …
human health. Angiopoietin-like-protein 8 (ANGPTL8) has previously been shown to form a …
Hydrogen–Deuterium Exchange Epitope Mapping of Glycosylated Epitopes Enabled by Online Immobilized Glycosidase
…, D Balasubramaniam, K Hughes, D Foster… - Analytical …, 2023 - ACS Publications
… interest is incubated in a D 2 O buffer, allowing the hydrogens to exchange with deuterium
for set time periods. The samples are subsequently diluted with non-D 2 O-containing buffers …
for set time periods. The samples are subsequently diluted with non-D 2 O-containing buffers …