Filaggrin in the frontline: role in skin barrier function and disease

A Sandilands, C Sutherland, AD Irvine… - Journal of cell …, 2009 - journals.biologists.com
… However, in rat and mouse profilaggrin, the C-terminal domain is much smaller and … During
processing, the N-terminal and C-terminal domains are cleaved from the parent profilaggrin …

[HTML][HTML] What Are the bona fide GSK3 Substrates?

C Sutherland - International journal of Alzheimer's Disease, 2011 - hindawi.com
… described GSK3 substrates require pre-phosphorylation at a residue 4 or 5 amino acids C-…
%, demonstrating the importance of the phosphorylated residue C-terminal to the target site. …

The epidemiology of Plasmodium falciparum gametocytes: weapons of mass dispersion

C Drakeley, C Sutherland, JT Bousema… - Trends in …, 2006 - cell.com
Much of the epidemiology of Plasmodium falciparum in Sub-Saharan Africa focuses on the
prevalence patterns of asexual parasites in people of different ages, whereas the …

[PDF][PDF] ULBPs, novel MHC class I–related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor

D Cosman, J Müllberg, CL Sutherland, W Chin… - Immunity, 2001 - cell.com
… extracellular domains were fused at their C termini to a modified leucine zipper motif with a
hexahistidine tag may not always predict protein expression. ULBP3 expression was highest …

Inactivation of glycogen synthase kinase-3β by phosphorylation: new kinase connections in insulin and growth-factor signalling

C Sutherland, IA Leighton, P Cohen - Biochemical Journal, 1993 - portlandpress.com
… Subsequently, it was implicated in the phosphorylation of transcription factors, such as c-jun
and c-myc [4-7], and in the regulation of several developmental processes in Drosophila [8,9]…

Dendritic cell survival and maturation are regulated by different signaling pathways

M Rescigno, M Martino, CL Sutherland… - The Journal of …, 1998 - rupress.org
Although dendritic cell (DC) activation is a critical event for the induction of immune responses,
the signaling pathways involved in this process have not been characterized. In this report…

A ten-year follow-up of one hundred consecutive Müller curved-stem total hip-replacement arthroplasties.

CJ Sutherland, AH Wilde, LS Borden, KE Marks - JBJS, 1982 - journals.lww.com
One hundred consecutive Müller curved-stem total hip replacements were reviewed ten
years after operation. Twenty patients with twenty-two arthroplasties had died within the ten-year …

[HTML][HTML] A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms

…, KD Silué, SB Sirima, C Sutherland… - … England Journal of …, 2016 - Mass Medical Soc
Background Recent gains in reducing the global burden of malaria are threatened by the
emergence of Plasmodium falciparum resistance to artemisinins. The discovery that mutations …

[HTML][HTML] Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing

…, C Hubbart, A Jeffreys, K Rowlands, C Sutherland… - Nature, 2012 - nature.com
Malaria elimination strategies require surveillance of the parasite population for genetic
changes that demand a public health response, such as new forms of drug resistance 1 , 2 . …

Two Nonrecombining Sympatric Forms of the Human Malaria Parasite Plasmodium ovale Occur Globally

CJ Sutherland, N Tanomsing, D Nolder… - The Journal of …, 2010 - academic.oup.com
Background . Malaria in humans is caused by apicomplexan parasites belonging to 5 species
of the genus Plasmodium. Infections with Plasmodium ovale are widely distributed but …