Sanaria Inc. has developed methods to manufacture, purify and cryopreserve aseptic Plasmodium
falciparum (Pf) sporozoites (SPZ), and is using this platform technology to develop an …

Controlled human infection (CHI) trials, in which healthy volunteers are experimentally infected,
can accelerate the development of novel drugs and vaccines for infectious diseases of …

More than 10 million people in western and central Africa are estimated to be infected with
Loa loa filarial nematodes. Like most other infectious diseases, L loa filariasis (loiasis) covers …

Background The replication-competent recombinant vesicular stomatitis virus (rVSV)–based
vaccine expressing a Zaire ebolavirus (ZEBOV) glycoprotein was selected for rapid safety …

A highly protective malaria vaccine would greatly facilitate the prevention and elimination of
malaria and containment of drug-resistant parasites 1 . A high level (more than 90%) of …

… by implementation of an Ag-specific memory B-cell ELISPOT. Since mature ASC are difficult
to access we generated them from circulating memory B-cells by maturation in the presence …

… DC determine the magnitude and quality of immune response by presenting Ags very
efficiently, activating lymphocytes including memory and naive T, B and NK cells, and producing a …

… B, NOS enzyme activity in PBMC immediately after separation from whole blood. Data are
… B, NOS enzyme activity in PBMC immediately after separation from whole blood. Data are …

… We reviewed other published gene targets (msp-1, dhfr, cytochrome b, microsatellite DNA
markers) and found striking homologies in all the markers without any specific identifying …

… ELISA results are depicted both as raw serum dilution curves (a, c) as well as the area
under curve (AUC) and the geometric mean/SD (b, d). a Serum dilution curves and b geometric …