Multiple system atrophy (MSA) is a sporadic neurodegenerative disease characterized
clinically by varying degrees of Parkinsonism, cerebellar ataxia and autonomic dysfunction and …

JNPL3 transgenic mice expressing a mutant tau protein, which develop neurofibrillary
tangles and progressive motor disturbance, were crossed with Tg2576 transgenic mice …

Neurofibrillary tangles (NFT) composed of the microtubule-associated protein tau are
prominent in Alzheimer disease (AD), Pick disease, progressive supranuclear palsy (PSP) and …

Neurofibrillary tangles, which consist of highly phosphorylated tau protein, and senile plaques
(SPs) are pathological hallmarks of Alzheimer’s disease (AD). In swollen axons, many …

Results of a standardized histochemical and immunocytochemical analysis of the brains of
14 nondemented elderly humans for whom prospective neurological and neuropsychological …

Immunocytochemistry with antibodies to ubiquitin is currently the most sensitive method for
detecting cortical Lewy bodies, which are a sine qua non for the diagnosis of diffuse Lewy …

Tau is the major component of the neurofibrillar tangles that are a pathological hallmark of
Alzheimers' disease. The identification of missense and splicing mutations in tau associated …

We performed phosphate of tau proteins isolated fromal human brain, tau associated with
paired helical filaments (PHF-tau), Alzheimerr tau not associated with PHF. These tau fractions …

Glial cytoplasmic inclusions (GCI) are the hallmark of multiple system atrophy (MSA), a rare
movement disorder frequently associated with autonomic dysfunction. In this study of 21 …

The intracellular assembly of tau aggregates is a pathological hallmark shared by Alzheimer's
disease and other neurodegenerative disorders known collectively as tauopathies. To …