Peroxisomal lipid degradation via β-and α-oxidation in mammals
…, PP Van Veldhoven, M Casteels - Cell biochemistry and …, 2000 - Springer
Peroxisomal β-oxidation is involved in the degradation of long chain and very long chain fatty
acyl-(coenzyme A)CoAs, long chain dicarboxylyl-CoAs, the CoA esters of eicosanoids, 2-…
acyl-(coenzyme A)CoAs, long chain dicarboxylyl-CoAs, the CoA esters of eicosanoids, 2-…
[HTML][HTML] Call for a dedicated European legal framework for bacteriophage therapy
…, R Lavigne, S Jennes, D De Vos, M Casteels… - Archivum immunologiae …, 2014 - Springer
The worldwide emergence of antibiotic resistances and the drying up of the antibiotic
pipeline have spurred a search for alternative or complementary antibacterial therapies. …
pipeline have spurred a search for alternative or complementary antibacterial therapies. …
Optimizing the European regulatory framework for sustainable bacteriophage therapy in human medicine
…, S Jennes, M Zizi, R Lavigne, M Casteels… - Archivum immunologiae …, 2012 - Springer
For practitioners at hospitals seeking to use natural (not genetically modified, as appearing
in nature) bacteriophages for treatment of antibiotic-resistant bacterial infections (…
in nature) bacteriophages for treatment of antibiotic-resistant bacterial infections (…
A mouse model for Zellweger syndrome
…, E Baumgart, P Carmeliet, M Casteels, M Fransen… - Nature …, 1997 - nature.com
The cerebro-hepato-renal syndrome of Zellweger is a fatal inherited disease caused by
deficient import of peroxisomal matrix proteins. The pathogenic mechanisms leading to extreme …
deficient import of peroxisomal matrix proteins. The pathogenic mechanisms leading to extreme …
Phytosterolemia in children with parenteral nutrition—Associated cholestatic liver disease
…, A Bowron, KA Mills, A Massoud, M Casteels… - Gastroenterology, 1993 - Elsevier
Background: Lipid emulsions used for parenterai nutrition (PN) contain phytosterols. Our
hypothesis was that these phytosterols can accumulate and contribute to cholestatic liver …
hypothesis was that these phytosterols can accumulate and contribute to cholestatic liver …
[HTML][HTML] Managed entry agreements for oncology drugs: lessons from the European experience to inform the future
K Pauwels, I Huys, S Vogler, M Casteels… - Frontiers in …, 2017 - frontiersin.org
Objectives: The aim of this study is to conduct an analysis on the regulation and application
of managed entry agreements (MEA) for oncology drugs across different European countries…
of managed entry agreements (MEA) for oncology drugs across different European countries…
[HTML][HTML] Insights into European drug shortages: a survey of hospital pharmacists
K Pauwels, S Simoens, M Casteels, I Huys - PloS one, 2015 - journals.plos.org
Drug shortages are a complex and global phenomenon. When a drug cannot be delivered at
the moment of patient demand, every stakeholder in the health care system is affected. The …
the moment of patient demand, every stakeholder in the health care system is affected. The …
[HTML][HTML] Drug shortages in European countries: a trade-off between market attractiveness and cost containment?
K Pauwels, I Huys, M Casteels, S Simoens - BMC health services research, 2014 - Springer
Background Drug shortages are a global problem. While extensively studied in the United
States, numbers about drug shortages in European countries are scarce. This study aims to …
States, numbers about drug shortages in European countries are scarce. This study aims to …
[HTML][HTML] Breakdown of 2-hydroxylated straight chain fatty acids via peroxisomal 2-hydroxyphytanoyl-CoA lyase: a revised pathway for the α-oxidation of straight chain …
…, GP Mannaerts, PP Van Veldhoven, M Casteels - Journal of Biological …, 2005 - ASBMB
… were measured in 20 mm Hepes-NaOH, pH 7.2, 25 μm BSA, 50 μm radioactive substrate, …
volume of 250 μl containing 50 mm Tris-HCl, pH 7.5, 6.6 μm BSA, 0.8 mm MgCl 2 , and 20 μ…
volume of 250 μl containing 50 mm Tris-HCl, pH 7.5, 6.6 μm BSA, 0.8 mm MgCl 2 , and 20 μ…
Causes of drug shortages in the legal pharmaceutical framework
…, S Simoens, L Hombroeckx, M Casteels… - Regulatory Toxicology …, 2015 - Elsevier
Introduction Different causes of drug shortages can be linked to the pharmaceutical legal
framework, such as: parallel trade, quality requirements, economic decisions to suspend or …
framework, such as: parallel trade, quality requirements, economic decisions to suspend or …