Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain
…, LD Altstiel, MH Bender, LN Boggs… - Journal of …, 2001 - Wiley Online Library
Converging lines of evidence implicate the beta‐amyloid peptide (Aβ) as causative in
Alzheimer's disease. We describe a novel class of compounds that reduce Aβ production by …
Alzheimer's disease. We describe a novel class of compounds that reduce Aβ production by …
Benign multilocular cystic nephroma: report of two cases of so-called multilocular cyst of the kidney
LK Boggs, P Kimmelstiel - The Journal of urology, 1956 - auajournals.org
… appearing connecti\·e ti8sue in the capsule of the mas;; and "scattered epithelial cell;,, in
the septa which had the appearance of tulrnk:-;," ln this respect hi:o case retiemhles case l of …
the septa which had the appearance of tulrnk:-;," ln this respect hi:o case retiemhles case l of …
Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor
…, F Martenyi, SM Sheehan, LN Boggs… - Journal of …, 2011 - Soc Neuroscience
According to the amyloid cascade hypothesis, cerebral deposition of amyloid-β peptide (Aβ)
is critical for Alzheimer's disease (AD) pathogenesis. Aβ generation is initiated when β-…
is critical for Alzheimer's disease (AD) pathogenesis. Aβ generation is initiated when β-…
The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs, and humans
…, SA Monk, PJ Cocke, JE Audia, LN Boggs… - Journal of …, 2015 - Soc Neuroscience
BACE1 is a key protease controlling the formation of amyloid β, a peptide hypothesized to
play a significant role in the pathogenesis of Alzheimer's disease (AD). Therefore, the …
play a significant role in the pathogenesis of Alzheimer's disease (AD). Therefore, the …
The 2009 schizophrenia PORT psychopharmacological treatment recommendations and summary statements
…, DL Kelly, JM Noel, DL Boggs… - Schizophrenia …, 2010 - academic.oup.com
In light of the large number of studies published since the 2004 update of Schizophrenia
Patient Outcomes Research Team psychopharmacological treatment recommendations, we …
Patient Outcomes Research Team psychopharmacological treatment recommendations, we …
Neurotoxicity of Human Amylin in Rat Primary Hippocampal Cultures: Similarity to Alzheimer's Disease Amyloid‐β Neurotoxicity
PC May, LN Boggs, KS Fuson - Journal of neurochemistry, 1993 - Wiley Online Library
… Amylin-induced neurotoxicity was morphologically similar to that induced by A@(l-40). In
contrast, the nonamyloidogenic rat arnylin showed negligible neurotoxicity despite having 95% …
contrast, the nonamyloidogenic rat arnylin showed negligible neurotoxicity despite having 95% …
More than just indicators: a review of tropical butterfly ecology and conservation
Roughly 90% of butterfly species live in the tropics. Despite this, we know very little about
tropical butterfly ecology particularly when compared to temperate butterfly systems. The …
tropical butterfly ecology particularly when compared to temperate butterfly systems. The …
Clusterin (Apo J) Protects Against In Vitro Amyloid‐β (1–40) Neurotoxicity
LN Boggs, KS Fuson, M Baez, L Churgay… - Journal of …, 1996 - Wiley Online Library
Clusterin is a secreted glycoprotein that is markedly induced in many disease states and after
tissue injury. In the CNS, clusterin expression is elevated in neuropathological conditions …
tissue injury. In the CNS, clusterin expression is elevated in neuropathological conditions …
[HTML][HTML] Origin of Elevated S-Glutathionylated GAPDH in Chronic Neurodegenerative Diseases
PA Hyslop, LN Boggs, MO Chaney - International Journal of Molecular …, 2023 - mdpi.com
H 2 O 2 -oxidized glyceraldehyde-3-phosphate dehydrogenase (GAPDH) catalytic cysteine
residues (C c (SH) undergo rapid S-glutathionylation. Restoration of the enzyme activity is …
residues (C c (SH) undergo rapid S-glutathionylation. Restoration of the enzyme activity is …
[BOOK][B] Community power, participation, conflict and development choice: Community wildlife conservation in the Okavango region of Northern Botswana
LP Boggs - 2000 - iied.org
… The primary management will fall to the DWNP after 1999, but a history of antagonistic
relationships between local communities and the DWNP (Boggs, in prep) could lead to a difficult …
relationships between local communities and the DWNP (Boggs, in prep) could lead to a difficult …