Malaria medicines to address drug resistance and support malaria elimination efforts

J Achan, J Mwesigwa, CP Edwin… - Expert review of clinical …, 2018 - Taylor & Francis
Introduction: Antimalarial drugs are essential weapons to fight malaria and have been used
effectively since the 17 th century. However, P.falciparum resistance has been reported to …

[HTML][HTML] On-going malaria transmission in The Gambia despite high coverage of control interventions: a nationwide cross-sectional survey

J Mwesigwa, J Okebe, M Affara, GL Di Tanna… - Malaria journal, 2015 - Springer
Background As indicators of burden of malaria have substantially decreased in The Gambia,
reaching a pre-elimination status may be attainable. Achieving this goal requires in-depth …

Pharmacokinetics of artemether-lumefantrine and artesunate-amodiaquine in children in Kampala, Uganda

J Mwesigwa, S Parikh, B McGee… - Antimicrobial agents …, 2010 - Am Soc Microbiol
The World Health Organization recommends the use of artemisinin-based combination
therapies (ACTs) for the treatment of uncomplicated malaria. The two most widely adopted ACT …

Hair concentrations of antiretrovirals predict viral suppression in HIV-infected pregnant and breastfeeding Ugandan women

CA Koss, P Natureeba, J Mwesigwa, D Cohan… - Aids, 2015 - journals.lww.com
Objective: Hair concentrations are a noninvasive measure of cumulative antiretroviral exposure
and the strongest predictor of viral suppression in large cohorts of nonpregnant patients. …

[HTML][HTML] Residual malaria transmission dynamics varies across The Gambia despite high coverage of control interventions

J Mwesigwa, J Achan, GL Di Tanna, M Affara… - PLoS …, 2017 - journals.plos.org
Over the last decades, malaria has declined substantially in The Gambia but its transmission
has not been interrupted. In order to better target control interventions, it is essential to …

[HTML][HTML] Optimisation and standardisation of a multiplex immunoassay of diverse Plasmodium falciparum antigens to assess changes in malaria transmission using …

…, H Vasileva, S Singh, M Affara, J Mwesigwa… - Wellcome open …, 2019 - ncbi.nlm.nih.gov
Background: Antibody responses have been used to characterise transmission and exposure
history in malaria-endemic settings for over a decade. Such studies have typically been …

[HTML][HTML] Foul wind, spirits and witchcraft: illness conceptions and health-seeking behaviour for malaria in the Gambia

S O'Neill, C Gryseels, S Dierickx, J Mwesigwa, J Okebe… - Malaria journal, 2015 - Springer
Background As the disease burden in the Gambia has reduced considerably over the last
decade, heterogeneity in malaria transmission has become more marked, with infected but …

Efficacy and safety of lopinavir/ritonavir versus efavirenz-based antiretroviral therapy in HIV-infected pregnant Ugandan women

…, CA Koss, A Plenty, F Luwedde, J Mwesigwa… - Aids, 2015 - journals.lww.com
Objective: Combination antiretroviral therapy (ART) is now the global standard for HIV-infected
pregnant and breastfeeding women at all CD4+ cell counts. We compared the efficacy …

Risk factors for preterm birth among HIV-infected pregnant Ugandan women randomized to lopinavir/ritonavir-or efavirenz-based antiretroviral therapy

…, A Plenty, F Luwedde, J Mwesigwa… - JAIDS Journal of …, 2014 - journals.lww.com
Background: Protease inhibitor–based antiretroviral therapy (ART) has been associated
with preterm birth in some studies. We examined risk factors for preterm birth among women …

[HTML][HTML] Reduced mosquito survival in metal-roof houses may contribute to a decline in malaria transmission in sub-Saharan Africa

…, J Mwesigwa, J Achan, N Bayoh, J Bradley… - Scientific reports, 2019 - nature.com
In The Gambia, metal-roof houses were hotter during the day than thatched-roof houses.
After 24 h, the mortality of Anopheles gambiae, the principal African malaria vector, was 38% …