… Guevara-Aguirre et al. (25) have reviewed the biochemical characteristics in 50 patients …
In a more extended study of the Ecuadorian GHRD population, Guevara-Aguirre et al. (24) …

Growth hormone (GH) has been used for over 35 years, and its safety and efficacy has been
studied extensively. Experimental studies showing the permissive role of GH/insulin-like …

Mice and humans with growth hormone receptor/IGF-1 deficiencies display major reductions
in age-related diseases. Because protein restriction reduces GHR-IGF-1 activity, we …

… A new study by Guevara-Aguirre et al. offers clues that address this seminal question.
The authors’ findings stem from studies of a unique group of Ecuadorian people who have a …

Obesity with insulin-resistant diabetes and increased cancer risk is a global problem. We
consider the alterations of metabolism attendant on the underlying pathogenic overnutrition …

To better understand the molecular genetic basis and genetic epidemiology of Laron syndrome
(growth-hormone insensitivity syndrome), we analyzed the growth-hormone receptor (…

IGF-I generation tests were developed over 20 yr ago and are currently used in differentiating
GH insensitivity (GHI) from other disorders characterized by low serum IGF-I. Nevertheless, …

Laron syndrome is an autosomal recessive condition characterized by resistance to growth
hormone. We sought to determine the molecular basis of this condition in an Ecuadorean …

We have identified 56 patients with GH receptor deficiency (Laron syndrome) from two
provinces in southern Ecuador, one group of 26 (Loja province) with a 4:1 female predominance …

We have reported 1-yr results of a double blind, placebo-controlled trial of recombinant
human insulin-like growth factor I (rhIGF-I) replacement in 16 children from the Ecuadorian GH …