4β‐hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans
U Diczfalusy, H Nylén, P Elander… - British journal of clinical …, 2011 - Wiley Online Library
We have proposed that 4β‐hydroxycholesterol (4β‐OHC) may be used as an endogenous
marker of CYP3A activity. The cholesterol metabolite 4β‐OHC is formed by CYP3A4. …
marker of CYP3A activity. The cholesterol metabolite 4β‐OHC is formed by CYP3A4. …
Comparison of endogenous 4β-hydroxycholesterol with midazolam as markers for CYP3A4 induction by rifampicin
L Björkhem-Bergman, T Bäckström, H Nylén… - Drug Metabolism and …, 2013 - ASPET
… Sample preparation was performed by protein precipitation with acetonitrile containing
internal standards [ 2 H 4 ]midazolam and [ 2 H 4 ]1′-hydroxymidazolam. We added 200 µl of …
internal standards [ 2 H 4 ]midazolam and [ 2 H 4 ]1′-hydroxymidazolam. We added 200 µl of …
Electronic structure of ZnO (0001) studied by angle-resolved photoelectron spectroscopy
…, S Söderholm, UO Karlsson, C Wigren, H Nylen… - Surface Science, 1997 - Elsevier
The electronic structure of the ZnO(0001) surface was studied by angle-resolved photoelectron
spectroscopy. The recorded normal emission spectra give information about the valence …
spectroscopy. The recorded normal emission spectra give information about the valence …
A comparison of 4β‐hydroxycholesterol: cholesterol and 6β‐hydroxycortisol: cortisol as markers of CYP3A4 induction
Y Mårde Arrhén, H Nylén… - British journal of …, 2013 - Wiley Online Library
… Urine was collected from 20.00 h to 08.00 h (12 h) before treatment and after 2 weeks of
treatment with rifampicin. All volunteers gave their written informed consent to participate in the …
treatment with rifampicin. All volunteers gave their written informed consent to participate in the …
Improvement of LWR thermal margins by introducing thorium
CW Lau, C Demazière, H Nylén, U Sandberg - Progress in Nuclear Energy, 2012 - Elsevier
The use of thorium in pressurized water reactor fuel assemblies is investigated in this paper.
The novelty of the reported work is to study a fuel design primarily intended to control the …
The novelty of the reported work is to study a fuel design primarily intended to control the …
Pharmacogenetic and pharmacokinetic aspects of CYP3A induction by efavirenz in HIV patients
…, W Amogne, E Makonnen, G Yimer, H Nylen… - The …, 2013 - nature.com
We investigated the effects of pharmacogenetic variations and efavirenz pharmacokinetics
on inter-individual differences in the extent of CYP3A induction by efavirenz using 4β-…
on inter-individual differences in the extent of CYP3A induction by efavirenz using 4β-…
Resonant photoelectron spectroscopy on NiO
…, UO Karlsson, G Chiaia, M Qvarford, H Nylén… - Physical Review B, 1996 - APS
Resonant photoelectron spectroscopy studies have been performed on the NiO valence
band at photon energies corresponding to the Ni 2 p, 3 p, and O 1 s absorption thresholds. …
band at photon energies corresponding to the Ni 2 p, 3 p, and O 1 s absorption thresholds. …
Influence of magnetic ordering on the NiO valence band
…, G Chiaia, R Girard, UO Karlsson, H Nylén… - Physical Review B, 1996 - APS
The influence of magnetic ordering on the NiO valence band has been studied by angle
resolved photoelectron spectroscopy. Measurements have been performed at temperatures …
resolved photoelectron spectroscopy. Measurements have been performed at temperatures …
mi RNA‐27b levels are associated with CYP 3A activity in vitro and in vivo
…, I Skilving, ML Ovesjö, E Aklillu, H Nylén… - Pharmacology …, 2015 - Wiley Online Library
Previous in vitro studies have shown that micro RNA ‐27b (miR‐27b) may regulate mRNA
levels of CYP 3A4, vitamin D receptor ( VDR ), and Peroxisome proliferator‐activated receptor …
levels of CYP 3A4, vitamin D receptor ( VDR ), and Peroxisome proliferator‐activated receptor …
Quinine compared to 4β-hydroxycholesterol and midazolam as markers for CYP3A induction by rifampicin
L Björkhem-Bergman, T Bäckström, H Nylén… - Drug metabolism and …, 2014 - Elsevier
When developing new drugs appropriate markers for detecting induction and inhibition of
cytochrome P450 3A enzymes (CYP3A) are needed. The aim of the present study was to …
cytochrome P450 3A enzymes (CYP3A) are needed. The aim of the present study was to …