Purpose: Germ-line mutations in the exonuclease domains of POLE and POLD1 have been
recently associated with polyposis and colorectal cancer (CRC) predisposition. Here, we …

Neurofibromatosis 2 (NF2) patients with constitutional splice site NF2 mutations have greater
variability in disease severity than NF2 patients with other types of mutations; the cause of …

Context Approximately 10% of women with invasive epithelial ovarian cancer (EOC) carry
deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2 -…

Many cancer-associated genes remain to be identified to clarify the underlying molecular
mechanisms of cancer susceptibility and progression. Better understanding is also required of …

… The identification of an epistatic effect between the HLA-C and LCE3C loci in the Dutch
population is notable because attempts to identify interaction between HLA-C and other loci …

This paper presents the results of experimental research into concrete produced by replacing
the natural aggregates with recycled aggregates coming from construction waste and …

… PCR reactions were performed with denaturation at 94C for 3 min, 40 cycles of 94C for
60 s, 58C for 60 s and 74C for 90 s, and a final extension at 74C for 10 min under standard …

The prevalence and spectrum of germline mutations in BRCA1 and BRCA2 have been reported
in single populations, with the majority of reports focused on White in Europe and North …

… Bacteria of the Clostridium genus, such as C. difficile and C. perfringens, are major … Lázaro
CP, Pondé MP, Rodrigues LE. Some biochemical implications in autism spectrum disorder. …

Neurofibromas are one of the most characteristic features of neurofibromatosis type 1 (NF1),
an inherited autosomal-dominant neurogenetic disorder affecting 1 in 3500 individuals …