Dynamic Dissolution Testing To Establish In Vitro/In Vivo Correlations for Montelukast Sodium, a Poorly Soluble Drug
A Okumu, M DiMaso, R Löbenberg - Pharmaceutical research, 2008 - Springer
Purpose The objectives of the study was to develop a dissolution test method that can be
used to predict the oral absorption of montelukast sodium, and to establish an in vitro/in vivo …
used to predict the oral absorption of montelukast sodium, and to establish an in vitro/in vivo …
Computer simulations using GastroPlus™ to justify a biowaiver for etoricoxib solid oral drug products
A Okumu, M DiMaso, R Löbenberg - European journal of pharmaceutics …, 2009 - Elsevier
PURPOSE: The purpose of this study was to compare the dissolution behaviour of etoricoxib
in different dissolution media and to establish in vitro/in vivo correlation (IVIVC) using …
in different dissolution media and to establish in vitro/in vivo correlation (IVIVC) using …
Sensitive and feasible specimen collection and testing strategies for diagnosing tuberculosis in young children
…, M Fajans, SK Musau, E Okeyo, A Okumu… - JAMA …, 2021 - jamanetwork.com
Importance Criterion-standard specimens for tuberculosis diagnosis in young children,
gastric aspirate (GA) and induced sputum, are invasive and rarely collected in resource-limited …
gastric aspirate (GA) and induced sputum, are invasive and rarely collected in resource-limited …
[HTML][HTML] The effect of elevated progesterone and pregnancy status on mRNA expression and localisation of progesterone and oestrogen receptors in the bovine uterus
To obtain further perspective on reproduction and particularly gamete function among so-called
primitive mammals presently grouped in the Order Insectivora, we have examined the …
primitive mammals presently grouped in the Order Insectivora, we have examined the …
Pregnancy and HIV transmission among HIV‐discordant couples in a clinical trial in Kisumu, Kenya
…, EA Bukusi, J Odoyo, J Achando, A Okumu… - HIV …, 2011 - Wiley Online Library
Objectives A large proportion of new HIV infections in sub‐Saharan Africa occur in stable
HIV‐discordant partnerships. In some couples, the strong desire to conceive a child may lead …
HIV‐discordant partnerships. In some couples, the strong desire to conceive a child may lead …
[HTML][HTML] Neuropathologic analysis of Tyr69His TTR variant meningovascular amyloidosis with dementia
JL Ziskin, MD Greicius, W Zhu, AN Okumu… - Acta neuropathologica …, 2015 - Springer
Transthyretin/TTR gene mutations usually cause systemic amyloidotic diseases. Few TTR
variants preferentially affect the central nervous system, manifesting as oculoleptomeningeal …
variants preferentially affect the central nervous system, manifesting as oculoleptomeningeal …
1, 3-Dioxane-linked bacterial topoisomerase inhibitors with enhanced antibacterial activity and reduced hERG inhibition
L Li, AA Okumu, S Nolan, A English… - ACS infectious …, 2019 - ACS Publications
The development of new therapies to treat methicillin-resistant Staphylococcus aureus (MRSA)
is needed to counteract the significant threat that MRSA presents to human health. Novel …
is needed to counteract the significant threat that MRSA presents to human health. Novel …
Optimization of TopoIV potency, ADMET properties, and hERG inhibition of 5-amino-1, 3-dioxane-linked novel bacterial topoisomerase inhibitors: Identification of a …
Y Lu, S Vibhute, L Li, A Okumu… - Journal of Medicinal …, 2021 - ACS Publications
Novel bacterial topoisomerase inhibitors (NBTIs) are among the most promising new antibiotics
in preclinical/clinical development. We previously reported dioxane-linked NBTIs with …
in preclinical/clinical development. We previously reported dioxane-linked NBTIs with …
Catalytic Antibodies May Contribute to Demyelination in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
…, ML Dafoe, J Wilhelmy, L Cervantes, AN Okumu… - Biochemistry, 2023 - ACS Publications
Here we report preliminary data demonstrating that some patients with myalgic
encephalomyelitis/chronic fatiguesyndrome (ME/CFS) may have catalytic autoantibodies that cause …
encephalomyelitis/chronic fatiguesyndrome (ME/CFS) may have catalytic autoantibodies that cause …
[HTML][HTML] Machine learning to predict bacteriologic confirmation of Mycobacterium tuberculosis in infants and very young children
…, E Okeyo, SK Musau, A Okumu… - PLOS Digital …, 2023 - journals.plos.org
Diagnosis of tuberculosis (TB) among young children (<5 years) is challenging due to the
paucibacillary nature of clinical disease and clinical similarities to other childhood diseases. …
paucibacillary nature of clinical disease and clinical similarities to other childhood diseases. …