Dynamic Dissolution Testing To Establish In Vitro/In Vivo Correlations for Montelukast Sodium, a Poorly Soluble Drug

A Okumu, M DiMaso, R Löbenberg - Pharmaceutical research, 2008 - Springer
Purpose The objectives of the study was to develop a dissolution test method that can be
used to predict the oral absorption of montelukast sodium, and to establish an in vitro/in vivo …

Computer simulations using GastroPlus™ to justify a biowaiver for etoricoxib solid oral drug products

A Okumu, M DiMaso, R Löbenberg - European journal of pharmaceutics …, 2009 - Elsevier
PURPOSE: The purpose of this study was to compare the dissolution behaviour of etoricoxib
in different dissolution media and to establish in vitro/in vivo correlation (IVIVC) using …

Sensitive and feasible specimen collection and testing strategies for diagnosing tuberculosis in young children

…, M Fajans, SK Musau, E Okeyo, A Okumu… - JAMA …, 2021 - jamanetwork.com
Importance Criterion-standard specimens for tuberculosis diagnosis in young children,
gastric aspirate (GA) and induced sputum, are invasive and rarely collected in resource-limited …

[HTML][HTML] The effect of elevated progesterone and pregnancy status on mRNA expression and localisation of progesterone and oestrogen receptors in the bovine uterus

LA Okumu, N Forde, AG Fahey, E Fitzpatrick… - …, 2010 - rep.bioscientifica.com
To obtain further perspective on reproduction and particularly gamete function among so-called
primitive mammals presently grouped in the Order Insectivora, we have examined the …

Pregnancy and HIV transmission among HIV‐discordant couples in a clinical trial in Kisumu, Kenya

…, EA Bukusi, J Odoyo, J Achando, A Okumu… - HIV …, 2011 - Wiley Online Library
Objectives A large proportion of new HIV infections in sub‐Saharan Africa occur in stable
HIV‐discordant partnerships. In some couples, the strong desire to conceive a child may lead …

[HTML][HTML] Neuropathologic analysis of Tyr69His TTR variant meningovascular amyloidosis with dementia

JL Ziskin, MD Greicius, W Zhu, AN Okumu… - Acta neuropathologica …, 2015 - Springer
Transthyretin/TTR gene mutations usually cause systemic amyloidotic diseases. Few TTR
variants preferentially affect the central nervous system, manifesting as oculoleptomeningeal …

1, 3-Dioxane-linked bacterial topoisomerase inhibitors with enhanced antibacterial activity and reduced hERG inhibition

L Li, AA Okumu, S Nolan, A English… - ACS infectious …, 2019 - ACS Publications
The development of new therapies to treat methicillin-resistant Staphylococcus aureus (MRSA)
is needed to counteract the significant threat that MRSA presents to human health. Novel …

Optimization of TopoIV potency, ADMET properties, and hERG inhibition of 5-amino-1, 3-dioxane-linked novel bacterial topoisomerase inhibitors: Identification of a …

Y Lu, S Vibhute, L Li, A Okumu… - Journal of Medicinal …, 2021 - ACS Publications
Novel bacterial topoisomerase inhibitors (NBTIs) are among the most promising new antibiotics
in preclinical/clinical development. We previously reported dioxane-linked NBTIs with …

Catalytic Antibodies May Contribute to Demyelination in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

…, ML Dafoe, J Wilhelmy, L Cervantes, AN Okumu… - Biochemistry, 2023 - ACS Publications
Here we report preliminary data demonstrating that some patients with myalgic
encephalomyelitis/chronic fatiguesyndrome (ME/CFS) may have catalytic autoantibodies that cause …

[HTML][HTML] Machine learning to predict bacteriologic confirmation of Mycobacterium tuberculosis in infants and very young children

…, E Okeyo, SK Musau, A Okumu… - PLOS Digital …, 2023 - journals.plos.org
Diagnosis of tuberculosis (TB) among young children (<5 years) is challenging due to the
paucibacillary nature of clinical disease and clinical similarities to other childhood diseases. …