In this study we used an interpretive, ethnographic, qualitative approach to examine Papua New Guinean women's narratives and perceptions about their health and the ways in which these were linked to coping with personal adversity. Women used a variety of strategies to cope with psychosocial stressors and challenging life circumstances, including both reliance on their own agency and active efforts and the seeking of social and spiritual support. We observed that limited access to social and economic resources, combined with gender constraints, made women socially and culturally vulnerable to social strain that affected their physical and emotional health. A number of women used avoidance strategies that were related to lower levels of self-esteem and life satisfaction and displayed high levels of anxiety. We propose the need to understand the context in which coping takes place and to enhance resilience strategies used by women in developing countries such as Papua New Guinea to manage the multiple stressors associated with confronting life's challenges.