Skip to main content

Advertisement

Log in

How many patients with post-chikungunya chronic inflammatory rheumatism can we expect in the new endemic areas of Latin America?

  • Short Communication - Observational Research
  • Published:
Rheumatology International Aims and scope Submit manuscript

Abstract

Post-chikungunya chronic inflammatory rheumatism (pCHIK-CIR) is one of the consequences that are impacting new endemic countries, such as those in the Americas. The relative frequency of pCHIK-CIR is highly variable, ranging from 14.4 % to 87.2 % (including variable number of patients and follow-up times). Based on those non-weighted values, it is difficult to estimate which would be the expected number of patients with CHIK who will develop CIR. For these reasons, we modeled weighted estimations based on pooled data extracted from those eight representative studies in order to provide cumulative proportion of pCHIK-CIR over time and median time of it, but also estimations of the number of patients with CHIK reported in Latin American countries (within a 95 % CI). This model estimated a prevalence of 47.57 % for pCHIK-CIR (95 % CI 45.08–50.13), with a median time to 50 % of pCHIK-CIR in 20.12 months. Given the reported number of patients with acute CHIK during 2014 in the Americas, our estimates suggest that from those patients, 385,835–429,058 patients will develop pCHIK-CIR. Despite the limitations of these estimates, the provided figures of pCHIK-CIR presented here are preliminary approximations of what the future burden of related rheumatic disease in the region as a consequence of CHIK infection for 2015–2016 could be, given the timeframe of median time of occurrence.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Cauchemez S, Ledrans M, Poletto C, Quenel P, de Valk H, Colizza V et al (2014) Local and regional spread of chikungunya fever in the Americas. Euro Surveill 19:20854

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  2. Clouet-Huerta D, Alfaro-Toloza P, Rodriguez-Morales AJ (2014) [Chikungunya in the Americas: preparedness, surveillance and alert in Chile]. Rev Chilena Infectol 31:761–762

    Article  PubMed  Google Scholar 

  3. Alfaro-Toloza P, Clouet-Huerta DE, Rodríguez-Morales AJ (2015) Chikungunya, the emerging migratory rheumatism. Lancet Infect Dis 15:510–512

    Article  PubMed  Google Scholar 

  4. Dupuis-Maguiraga L, Noret M, Brun S, Le Grand R, Gras G, Roques P (2012) Chikungunya disease: infection-associated markers from the acute to the chronic phase of arbovirus-induced arthralgia. PLoS Neglect Trop Dis 6:e1446

    Article  Google Scholar 

  5. Javelle E, Ribera A, Degasne I, Gauzere BA, Marimoutou C, Simon F (2015) Specific management of post-chikungunya rheumatic disorders: a retrospective study of 159 cases in reunion island from 2006–2012. PLoS Neglect Trop Dis 9:e0003603

    Article  Google Scholar 

  6. Borgherini G, Poubeau P, Jossaume A, Gouix A, Cotte L, Michault A et al (2008) Persistent arthralgia associated with chikungunya virus: a study of 88 adult patients on reunion island. Clin Infect Dis 47:469–475

    Article  PubMed  Google Scholar 

  7. Chaaithanya IK, Muruganandam N, Raghuraj U, Sugunan AP, Rajesh R, Anwesh M et al (2014) Chronic inflammatory arthritis with persisting bony erosions in patients following chikungunya infection. Indian J Med Res 140:142–145

    PubMed Central  PubMed  Google Scholar 

  8. Chopra A, Anuradha V, Ghorpade R, Saluja M (2012) Acute Chikungunya and persistent musculoskeletal pain following the 2006 Indian epidemic: a 2-year prospective rural community study. Epidemiol Infect 140:842–850

    Article  CAS  PubMed  Google Scholar 

  9. Gerardin P, Fianu A, Michault A, Mussard C, Boussaid K, Rollot O et al (2013) Predictors of chikungunya rheumatism: a prognostic survey ancillary to the TELECHIK cohort study. Arthr Res Therapy 15:R9

    Article  Google Scholar 

  10. Hoarau JJ, Jaffar Bandjee MC, Krejbich Trotot P, Das T, Li-Pat-Yuen G, Dassa B et al (2010) Persistent chronic inflammation and infection by chikungunya arthritogenic alphavirus in spite of a robust host immune response. J Immunol 184:5914–5927

    Article  CAS  PubMed  Google Scholar 

  11. Manimunda SP, Vijayachari P, Uppoor R, Sugunan AP, Singh SS, Rai SK et al (2010) Clinical progression of chikungunya fever during acute and chronic arthritic stages and the changes in joint morphology as revealed by imaging. Trans R Soc Trop Med Hyg 104:392–399

    Article  PubMed  Google Scholar 

  12. Win MK, Chow A, Dimatatac F, Go CJ, Leo YS (2010) Chikungunya fever in Singapore: acute clinical and laboratory features, and factors associated with persistent arthralgia. J Clin Virol 49:111–114

    Article  CAS  PubMed  Google Scholar 

  13. Pan-American Health Organization (2015) Number of reported cases of chikungunya in countries or territories of the Americas 2013–2015 (Epidemiological week 1, January 9, 2015)

  14. Horcada ML, Diaz-Calderon C, Garrido L (2015) Chikungunya fever. Rheumatic manifestations of an emerging disease in Europe. Reumatol Clin 11:161–164

    Article  PubMed  Google Scholar 

  15. Chopra A, Saluja M, Venugopalan A (2014) Effectiveness of chloroquine and inflammatory cytokine response in patients with early persistent musculoskeletal pain and arthritis following chikungunya virus infection. Arthr Rheumatol 66:319–326

    Article  CAS  Google Scholar 

  16. Delogu I, de Lamballerie X (2011) Chikungunya disease and chloroquine treatment. J Med Virol 83:1058–1059

    Article  PubMed  Google Scholar 

  17. Ganu MA, Ganu AS (2011) Post-chikungunya chronic arthritis–our experience with DMARDs over two year follow up. J Assoc Phys India 59:83–86

    Google Scholar 

  18. Ribera A, Degasne I, Jaffar Bandjee MC, Gasque P (2012) [Chronic rheumatic manifestations following chikungunya virus infection: clinical description and therapeutic considerations]. Med Trop 72 Spec No: 83–85

  19. Simon F, Parola P, Grandadam M, Fourcade S, Oliver M, Brouqui P et al (2007) Chikungunya infection: an emerging rheumatism among travelers returned from Indian Ocean islands. Report of 47 cases. Medicine 86:123–137

    Article  PubMed  Google Scholar 

  20. Rothan HA, Bahrani H, Mohamed Z, Teoh TC, Shankar EM, Rahman NA et al (2015) A combination of doxycycline and ribavirin alleviated chikungunya infection. PLoS One 10:e0126360

    Article  PubMed Central  PubMed  Google Scholar 

Download references

Conflict of interest

None.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A. J. Rodriguez-Morales.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rodriguez-Morales, A.J., Cardona-Ospina, J.A., Villamil-Gómez, W. et al. How many patients with post-chikungunya chronic inflammatory rheumatism can we expect in the new endemic areas of Latin America?. Rheumatol Int 35, 2091–2094 (2015). https://doi.org/10.1007/s00296-015-3302-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00296-015-3302-5

Keywords

Navigation