Table 4

Effect of PTM202 on duration of diarrhoea among Guatemalan children by the presence of individual pathogen at urban site enrolment

Pathogen	Intervention	n	Median	HR	95% CI	P value*
Pathogen	Intervention	n	hours	HR	95% CI	P value*
ETEC†	PTM202	16	27.0	1.86	0.93 to 3.70	0.08
ETEC†	Placebo	21	35.8	1.86	0.93 to 3.70	0.08
STEC/0157†	PTM202	5	3.0	12.17	1.38 to 107.84	0.025
STEC/0157†	Placebo	6	28.9	12.17	1.38 to 107.84	0.025
Rotavirus†	PTM202	6	20.1	1.38	0.41 to 4.67	0.60
Rotavirus†	Placebo	6	41.5	1.38	0.41 to 4.67	0.60
Salmonella†	PTM202	1	N/A	2.45	0.15 to 39.72	0.53
Salmonella†	Placebo	3	41.9	2.45	0.15 to 39.72	0.53
Norovirus‡	PTM202	26	24.6	1.66	0.94 to 2.94	0.08
Norovirus‡	Placebo	27	30.9	1.66	0.94 to 2.94	0.08
Shigella (EIEC)‡	PTM202	14	25.6	2.52	0.88 to 7.23	0.09
Shigella (EIEC)‡	Placebo	7	41.1	2.52	0.88 to 7.23	0.09
Campylobacter	PTM202	16	25.0	1.67	0.74 to 3.78	0.22
Campylobacter	Placebo	11	39.8	1.67	0.74 to 3.78	0.22
Clostridium difficile	PTM202	5	22.6	6.43	1.17 to 35.29	0.03
Clostridium difficile	Placebo	7	30.9	6.43	1.17 to 35.29	0.03
Plesiomonas	PTM202	1	N/A	N/A	N/A	N/A
Plesiomonas	Placebo	1	N/A	N/A	N/A	N/A
Enteroaggregative Escherichia coli	PTM202	33	25.6	1.15	0.71 to 1.89	0.57
Enteroaggregative Escherichia coli	Placebo	32	30.1	1.15	0.71 to 1.89	0.57
Enteropathogenic E. coli	PTM202	27	25.6	1.63	0.94 to 2.83	0.08
Enteropathogenic E. coli	Placebo	29	30.9	1.63	0.94 to 2.83	0.08
Cryptosporidium	PTM202	3	19.0	1.70	0.34 to 8.62	0.52
Cryptosporidium	Placebo	4	33.9	1.70	0.34 to 8.62	0.52
Giardia	PTM202	7	5.2	2.27	0.47 to 11.04	0.31
Giardia	Placebo	3	17.2	2.27	0.47 to 11.04	0.31
Adenovirus	PTM202	8	23.4	1.53	0.52 to 4.50	0.44
Adenovirus	Placebo	7	65.7	1.53	0.52 to 4.50	0.44
Astrovirus*	PTM202	3	22.6	2.09	1.57 to 2.79	<0.0001
Astrovirus*	Placebo	3	46.3	2.09	1.57 to 2.79	<0.0001
Sapovirus	PTM202	7	35.8	0.89	0.31 to 2.55	0.83
Sapovirus	Placebo	9	41.4	0.89	0.31 to 2.55	0.83

*HR not calculable due to bimodal distribution of the data; risk ratio using Poisson distribution is presented.
†Organism directly targeted by PTM202.
‡Organism indirectly targeted by PTM202.
EIEC, enteroinvasive E.coli; ETEC, enterotoxigenic E.coli.