Unadjusted and adjusted incidence estimates of neonatal conditions requiring inpatient care
| Conditions | Unadjusted estimate (bounds of confidence*) per 1000 live births | Adjusted estimates (bounds of confidence) per 1000 live births | Already excluded in unadjusted estimates† | Excluded by adjustment‡ | GRADE§ |
| <32 weeks preterm | 14.60 (11.90–17.80) | 14.60 (11.90–17.80) | TOP, GA <22 weeks, stillbirths | Not possible to adjust | ⊕⊕⊕◯ |
| BW <2000 g | 31.22 (27.20–35.80) | 14.31 (12.47–16.41) | Stillbirths | Those with other diagnoses in the framework | ⊕◯◯◯ |
| Neonatal encephalopathy | 8.63 (6.10–13.30) | 8.63 (6.10–13.30) | ‘Where possible’ GA <34 weeks, BW <2000 g, severe infection, congenital malformations, stillbirths | Not possible to adjust | ⊕⊕⊕◯ |
| Neonatal respiratory diseases | 24.56 (24.19–24.93) | 17.09 (16.74–17.43) | RDS/TTN–GA <30 weeks, multiple pregnancies; MAS–GA <24 weeks, BW <500 g, multiple pregnancies, stillbirths | GA <32 weeks | ⊕⊕◯◯ |
| Severe infection | 62.00 (41.00–83.00) | 62.00 (41.00–83.00) | BW <500 g, GA <32 weeks, stillbirths | Not possible to adjust | ⊕⊕◯◯ |
| Jaundice requiring treatment | 73.87 (67.10–81.20) | 63.60 (57.70–69.91) | Stillbirths | Severe infection | ⊕◯◯◯ |
| Major congenital malformations¶ | 8.32 (6.07–10.02) | 2.86 (2.31–3.42) | Nil | GA <32 weeks | ⊕⊕◯◯ |
| Total | 223.19 (183.36–266.25)** | 183.09 (148.10–221.46)** |
*95% CIs apart from in the case of ‘major congenital malformations’ (see supplementary appendix 1 for details).
†Excluded in primary data source.
‡Excluded following adjustment for overlap.
§Evaluation of confidence in estimates based on the GRADE framework.
¶Further details of the incidence estimates for major congenital malformation groupings are provided in online supplementary appendix 2 table S2.
**Lower and higher estimates calculated by summing lower and upper bounds of confidence, respectively.