Descriptive statistics and analysis of child laboratory outcomes at 36 months by treatment group, with adjusted and unadjusted models (n=1017)
| Laboratory outcomes | Values 32 weeks gestation* | Values 36 months* | Unadjusted model effect† (95% CI) | Adjusted model effect†‡ (95% CI) |
| Haemoglobin (g/dL) | ||||
| Daily IFA | 12.4 [1.2] | 11.7 [0.9] | Reference | Reference |
| Twice-weekly IFA | 12.4 [1.2] | 11.7 [0.9] | 0.05 (–0.10 to 0.19) | 0.09 (–0.06 to 0.25) |
| Twice-weekly MMN | 12.3 [1.2] | 11.7 [1.0] | 0.01 (–0.21 to 0.22) | 0.01 (–0.20 to 0.22) |
| Anaemia (Hb<11.0 g/dL) | ||||
| Daily IFA | 35/344 (10.2) | 58 (18.1) | Reference | Reference |
| Twice-weekly IFA | 33/361 (9.1) | 62 (18.5) | 1.03 (0.69 to 1.53) | 1.02 (0.67 to 1.56) |
| Twice-weekly MMN | 42/318 (13.2) | 60 (19.3) | 1.08 (0.65 to 1.80) | 1.08 (0.65 to 1.79) |
| Ferritin (μg/L)‡ | ||||
| Daily IFA | 32 {24 to 55} | 35{21 to 55} | Reference | Reference |
| Twice-weekly IFA | 26 {18 to 37} | 35 {21 to 52} | 0.08 (–0.07 to 0.22) | 0.07 (–0.08 to 0.22) |
| Twice-weekly MMN | 21 {14 to 34} | 35.5 {20 to 53.5} | 0.01 (–0.15 to 0.18) | 0.01 (–0.25 to 0.18) |
| Iron deficiency (ferritin<12 μg/L) | ||||
| Daily IFA | 3/342 (0.9) | 12 (4.3) | Reference | Reference |
| Twice-weekly IFA | 8/361 (2.2) | 10 (3.4) | 0.79 (0.31 to 2.04) | 0.92 (0.35 to 2.40) |
| Twice-weekly MMN | 19/315 (6.0) | 15 (5.6) | 1.31 (0.63 to 2.71) | 1.49 (0.65 to 3.41) |
| B12 (pmol/L)‡ | ||||
| Daily IFA | 230.5 {184 to 279} | 530 {405 to 678} | Reference | Reference |
| Twice-weekly IFA | 229 {187 to 285} | 512 {392 to 680} | −0.01 (–0.10 to 0.09) | -0.01 (-1.0 to 0.10) |
| Twice-weekly MMN | 233 {187 to 287.5} | 502 {405 to 650.5} | 0.02 (–0.08 to 0.11) | 0.02 (-0.07 to 0.11) |
*Data are mean [SD], number (%) or median {25th to 75 centile}.
†Effect is difference in means for haemoglobin, ferritin and B12 and OR for anaemia and iron deficiency.
‡Log base 2 transformed for statistical analysis.
§Adjusted for maternal age, parity, maternal education, maternal body mass index, maternal pathology at 32 weeks and clustering.
IFA, iron-folic acid; MMN, multiple micronutrients.