Table 1

Comparison of methods for assessing cost-effectiveness

Cost-effectiveness analysis (CEA)Cost-utility analysis subtype of CEACost-benefit analysis (CBA)Social return on investment (SROI)
Main objective
Compare costs and outcomes of alternatives within the same domainCompare costs and outcome of alternatives within the same domainAssess worthwhileness of the investment made in implementing an interventionAssess worthwhileness of the investment made in implementing an intervention, from the perspective of stakeholders
Accounting for costs
Monetary value. Multiple sources can be explored, including direct and indirect costs as well as different perspectivesMonetary value
Multiple sources can be explored, including direct and indirect costs as well as different points of view
Monetary value
Multiple sources can be explored, including direct and indirect costs as well as different perspectives
Monetary value
Multiple sources can be explored, including direct and indirect costs as well as different perspectives
Accounting for benefits
Benefits referred to as ‘effectiveness’, which is reported as ‘natural units’ such as life years gained.Benefits referred to as ‘utility’, which is reported as quality adjusted life years gained/disability adjusted life years averted/healthy life years gainedBenefits include both health and non-health outcomes, which are reported as monetary value or welfare benefit. Benefits that are difficult to monetise are listedBenefits include both health and non-health outcomes, including social, economic and environmental outcomes. Both positive and negative effects are accounted for. Benefits are reported as monetary value or welfare benefit, using financial proxies to show monetary value of benefits that cannot be easily monetised.
Level of application
Single intervention levelSingle intervention levelSingle or multiple intervention(s), project or programme levelSingle or multiple intervention(s), project, programme, policy or organisation level
Time line of analysis
Retrospective or prospectiveRetrospective or prospectiveRetrospective or prospectiveRetrospective (evaluative type) or prospective (forecast type)
Discounting of future value
ApplicableApplicableApplicableApplicable
Stakeholder engagement
Not requiredNot requiredNot requiredMultiple stakeholders required
Theory of change
Not required for conductNot required for conductNot required for conductRequired for conduct
Main output of analysis
Incremental cost-effectiveness ratio (ICER). Sensitivity analysis is applicableICER. Sensitivity analysis is applicableBenefit-cost ratio (BCR), economic internal rate of return, net present value (NPV), break-even point. Sensitivity analysis is applicableSROI ratio, NPV, payback period.
Sensitivity analysis is applicable
Interpretation of main output of analysis
Intervention with higher cost-effectiveness ratio is betterIntervention with higher cost-effectiveness ratio is betterBCR >1 is worthwhile investmentSROI ratio >1 is worthwhile investment
Relevance
Priority setting and resource allocationPriority setting and resource allocationPriority setting and resource allocationPriority setting, resource allocation, stakeholder relationship building, accountability framework and management tool