Multivariate adjusted odds ratios for in-hospital mortality associated with clinical and laboratory data from patients pooled from hospital-based cohort studies conducted in six African countries from 2009 to 2015
| Clinical data alone (n=5573) | Clinical data and HIV serostatus known (n=3402) | Clinical data and HIV-infected (n=2122) | Clinical and laboratory data (n=1513) | |
| Female, aOR (95% CI) | 0.99 (0.85 to 1.16) | 1.14 (0.95 to 1.39) | 1.07 (0.86 to 1.33) | 1.16 (0.90 to 1.51) |
| Age (year), aOR (95% CI) | 1 (1 to 1.01) | 1 (1 to 1.01) | 1 (0.99 to 1.01) | 1 (0.99 to 1.01) |
| GCS score, aOR (95% CI) | 0.75 (0.73 to 0.78) | 0.72 (0.69 to 0.75) | 0.71 (0.67 to 0.75) | 0.73 (0.69 to 0.78) |
| Temperature (°C), aOR (95% CI) | 0.85 (0.81 to 0.9) | 0.78 (0.73 to 0.84) | 0.80 (0.74 to 0.87) | 0.81 (0.74 to 0.89) |
| Heart rate (per 10 bpm), aOR (95% CI) | 1.1 (1.1 to 1.2) | 1.1 (1.1 to 1.2) | 1.1 (1 to 1.1) | 1 (1 to 1.1) |
| Respiratory rate (per 5 brpm), aOR (95% CI) | 1.2 (1.2 to 1.3) | 1.2 (1.1 to 1.2) | 1.2 (1.1 to 1.2) | 1.2 (1.1 to 1.2) |
| SBP (per 10 mm Hg), aOR (95% CI) | 0.9 (0. 9 to 1) | 1 (0.9 to 1) | 1 (0.9 to 1.1) | 1 (0.9 to 1) |
| DBP (per 10 mm Hg), aOR (95% CI) | 0.9 (0.9 to 1) | 0.9 (0.82 to 1) | 0.9 (0.82 to 1) | 0.9 (0.82 to 1) |
| Oxygen saturation (%), aOR (95% CI) | 0.98 (0.97 to 0.99) | 0.96 (0.95 to 0.98) | 0.96 (0.94 to 0.98) | 0.97 (0.94 to 1) |
| HIV-infected, aOR (95% CI) | 2.9 (2.28 to 3.71) | |||
| CD4 count (per 50 cells/µL), aOR (95% CI) | 1 (1 to 1) | |||
| WBC (103/µL), aOR (95% CI) | 0.99 (0.96 to 1.01) | |||
| Haemoglobin concentration (g/dL), aOR (95% CI) | 0.91 (0.87 to 0.95) | |||
| Platelet concentration (103/µL), aOR (95% CI) | 1 (1 to 1) | |||
| Lactate concentration (mmol/L), aOR (95% CI) | 1.07 (1.02 to 1.12) | |||
| Area under the curve (95% CI) | 0.74 (0.72 to 0.76) | 0.78 (0.76 to 0.79) | 0.72 (0.69 to 0.74) | 0.71 (0.68 to 0.74) |
aOR, adjusted odds ratio; bpm, beats per minute; brpm, breaths per minute; CD, cluster of differentiation; DBP, diastolic blood pressure; GCS, Glasgow Coma Scale; SBP, systolic blood pressure; WBC, white blood cell concentration.